• English
    • français
  • English 
    • English
    • français
  • Login
View Item 
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Pure and Applied Sciences
  • RP-Department of Plant and Microbial Sciences
  • View Item
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Pure and Applied Sciences
  • RP-Department of Plant and Microbial Sciences
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Profile of HIV type 1 coreceptor tropism among Kenyan patients from 2009 to 2010.

Thumbnail
View/Open
Abstract (146.3Kb)
Date
2013
Author
Nyamache, A. K.
Muigai, A. W.
Ng'ang'a, Z.
Khamadi, S. A.
Metadata
Show full item record
Abstract
A switch of HIV coreceptor usage from CCR5 to CXCR4 occurs in AIDS pathogenesis and may play a critical role in the use of entry inhibitors. To determine the potential usefulness of maraviroc and other CCR5 antagonists among drug-naive and experienced patients in Kenya, the env-C2-V3 gene was successfully sequenced in samples from 176 (98 men and 78 female) consenting subjects between January 2009 and December 2012. In silico CPSSM, webPSSM/, and (ds) Kernel tools were used in predicting coreceptor usage. On the basis of the env V3 loop sequences, 84.1% (148) were reported with R-5 tropism, 4.5% (5) were dual tropic, while 13.4% (23) were of X4 tropism. However, similar to previous studies conducted in Kenya on genetic diversity, HIV-1 subtype A1 (73.9%; 130/176) still remains the most dominant subtype. The high levels of R5 tropism among the studied Kenyan infected populations suggested the potential use of CCR5 antagonists as new therapeutic options in Kenya.
URI
http://ir-library.ku.ac.ke/handle/123456789/7377
Collections
  • RP-Department of Plant and Microbial Sciences [274]

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback

 

 

Browse

All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback