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dc.contributor.authorMulakoli, Festus
dc.contributor.authorGichure, Michael
dc.date.accessioned2020-09-10T07:36:44Z
dc.date.available2020-09-10T07:36:44Z
dc.date.issued2020
dc.identifier.citationMulakoli, F., & Gichure, M. (2020). The prevalence of antibodies to Hepatitis B core antigen among blood donors in a tertiary institution in Nairobi County, Kenya. East Africa Science, 2(1), 36-44.en_US
dc.identifier.issn2664-1003
dc.identifier.urihttp://easci.eahealth.org/index.php/easci/article/view/24
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/20305
dc.descriptionA research article published in East Africa Scienceen_US
dc.description.abstractBackground: Infections linked to blood transfusion or tissue transplants prove to be a major challenge globally because of the serological window period (WP) and a latent stage exhibited by most viral infections. The objective of this study was to determine the prevalence of anti-HBc antibodies in HBsAg negative donors at Aga Khan University Hospital Nairobi. Methods: The current project was a cross-sectional study in which 76 donor samples that tested negative for HBsAg marker were reevaluated with an anti-HBc ELIA kit (Elecsys reagent kit) following Cobas 601(Roche, Stuttgart, Germany) machine operation manual. Anti-HBc positive samples were confirmed for positivity using polymerase chain reaction (PCR). Donor demography and risk factors such as age; gender, marital status, employment status, and donor type were reviewed and documented from the archived questionnaires. Results: In total, 76 archived samples were screened during the period of the study. The study population had an average age of 32 ± 8 years which male donors dominating at n=61 (79.2 %) and female n=16 (20.8 %). The prevalence rate of anti-HBc Total was 13 % during the period of the study. On further analysis of the 10 anti-HBc positive samples with PCR, there was no detectable HBV-DNA. The majority (63.6 %) of Anti-HBc positive cases were first-time donors and blood donors aged between 25–45 years being the majority. Conclusions: The introduction of anti-HBc as a routine screening tool is recommended to all potential blood donors and even in other medical procedures such as dialysis. These support the need for a duo approach when screening potential donors to rule out occult infection.en_US
dc.language.isoenen_US
dc.publisherEast Africa Health Research Commissionen_US
dc.subjectAntibodiesen_US
dc.subjectHepatitis B virusen_US
dc.subjectanti-Hepatitis B core totalen_US
dc.subjectTransfusionen_US
dc.subjectBlood donoren_US
dc.subjectWindow perioden_US
dc.titleThe prevalence of antibodies to Hepatitis B core antigen among blood donors in a tertiary institution in Nairobi County, Kenyaen_US
dc.typeArticleen_US


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