Haematological reference intervals for adolescents and adults in nakuru county, Kenya
Gachie, Rose Nyambura
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The haematologic reference intervals are important in the assessment of health and diseases conditions in a certain population and they vary with to age, sex, altitude and genetic. The current study intended to establish the haematological reference intervals in Nakuru County, Kenya. A cross sectional design was used where samples of blood were collected from consenting participants. The number of participants recruited for the study was 627 and they aged 13 to 18 years for the adolescents and 19 to 55 years for the adults. The erythrocyte median and reference indices (RBC count, P <0.0001; Hb, P <0.0001; HCT, P <0.0001; MCH, P =0.034; and MCHC, P <0.0001) were significantly different across the study groups. Post-hoc analyses showed that the median and reference HB, RBC, MCH, HCT, and MCHC counts were lower in female adults compared to male adults (P <0.05). Furthermore, median and reference values for MCHC were lower in the female adults compared to male adults, female adolescents and male adolescents (P <0.0001, respectively). The median and reference for Hb, MCH, RBC, Hct, and MCHC values in the male adults were however, higher in comparison to female adolescents (P <0.0001, respectively) while Hct was also lower in comparison to male adolescents (P <0.01). Finally, the median and reference Hb, Hct, RBC and MCH values were lower in the female adolescents compared to the male adolescents P <0.0001 for all). The median and the reference levels for the absolute monocyte and eosinophil counts showed statistical significance (monocyte, P <0.0001; eosinophil, P <0.001). Consequent analysis indicated differences with females adolescents having higher values than male adolescents p, <0.0001 for monocytes counts. The females indicated higher median and reference differential count levels for [lymphocytes (P<0.012), monocytes (P<0.031) and basophils (P<0.0001) than male and the values showed statistical significant (p <0.05). Post hoc indicated statistical differences within study groups with females having higher median and higher reference values for a lymphocytes and monocytes than the males adults (P<0.05) and male adolescents (P <0.0001). Age differences were also noted for lymphocytes, monocytes and basophils with female adults having lower values than the adults (P<0.0001). Females had higher median levels for absolute platelet counts than males and there was statistical difference (P <0.0001). Adult males also showed higher reference values than the male adolescents (P <0.0001). MPV also illustrated higher medium levels in females than males for adolescent (P <0.05). Further analysis indicated statistical significance with females having higher values (P <0.0001). Age differences were noted with male adults versus male adolescents for MPV (P <0.05). The results indicated low haematological reference values as compared to the currently utilized values by the clinicians in Kenya and also in Nakuru County. These data will therefore provide haematological reference values for this specific region which can also be interpolated in other regions for correct patients’ management and for clinical care.