Synthetic BicycIic Analogues of Quassinoids
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Date
1998
Authors
Thoruwa, C. L.
Watt, Robert A.
Toth, Istvan
Phillipson, David J.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
A series of simple bicyclic analogues of quassinoids have been prepared including compounds with ring A
typical of bruccolides and dehydrobruceolides. The synthesis of bicyclic compound 5 and tricyclic analogue 6 was
accomplished by acid catalysed Robinson Annelation reaction. Hydroxyketone 9a and its 2-substituted analogues were
also prepared to study the structure activity relationship.
Description
Research Article