Synthetic BicycIic Analogues of Quassinoids

Abstract

A series of simple bicyclic analogues of quassinoids have been prepared including compounds with ring A typical of bruccolides and dehydrobruceolides. The synthesis of bicyclic compound 5 and tricyclic analogue 6 was accomplished by acid catalysed Robinson Annelation reaction. Hydroxyketone 9a and its 2-substituted analogues were also prepared to study the structure activity relationship.