Gender related effects of yeast selenium on weight for age z score of asymptomatic HIV type 1 positive children at Nyamasaria in Kisumu Kenya
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Date
2015
Authors
Otieno, S.B.
Were, F.
Kabiru, Ephantus W.
K. Waza
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Abstract
Background: Selenoprotein Iodothyronine 5’Deiodonases activates pro-T3 to 3,3’-
5T3(Tri-iodothyronine) which is involved in growth through a gene mediated protein
metabolism. Oestradiol (E2) enhances activity of selenoproteins in adult pre-menopausal
women taking selenium supliments, however the effect of selenium supplementation on
weight change of different gender of asymptomatic HIV positive pre-puberty children is
still unknown.
Methods: In this study of 25 Females and 25 Males randomly chosen asymptomatic HIV
positive children 3 – 16 years old, 25 of the children were given, a fixed dose of 50μg
yeast selenium while a matched control of 25 were put on placebo. Weight of children
were taken at 3 months intervals up to 6 months, using electronic personal scale (model
10010), the resultant data was analyzed by Epi Info version 6,and SPSS version 16.
Results: No significant difference in mean weight of children was observed at baseline
between the controls and children on test . Children on selenium had weight increase of
2.5Kg at six months .The weight for age Z score increased above -2SDs cut off point at
six months amongst the children on selenium, in all age categories, 3-5 years 1.20 ±
2.45, 6-8years 0.19 ± 0.880, 9-15 years 0.97 ± 1.22, while there was a decrease in all
the age categories in matched controls to below -2SDs at six months , 3-5 years -2.218 ±
1.46, 6-8 years -2.95. ± 3.10, 9-15 -2.30 ± 1.240. There was a significant WAZ
difference between controls and selenium group at six months {F (5,12) = =5.758,
P=0.006}. Prevalence of underweight in control was 48% compared to the test group at
9% at six months. Female children on selenium initially had a decrease and then sharp
increase in WAZ (Tick Phenomenon), compared to the males who had a steady increase
in WAZ.
Conclusion: It can be concluded that intake of yeast Selenium led to significant
improvement in weight for age Z score at six months and further that there is gender
related differences in weight change between HIV positive asymptomatic female and male
children taking selenium as a supplement
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Citation
International Journal of Current Advanced Research Vol 4, Issue 7, pp 194-199, July 2015