Cellular Immune Response and Abomasum worm burden in Goats Vaccinated with HC58cDNA Vaccine against H. contortus Infection
Osuga, Isaac M.
Muleke, C. I.
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Abstract Vaccination with DNA vaccines derived from adult H. contortus induces significant level of protection against homologous infection in goat. To date however, mechanism of protection is not well understood, especially in goat. In this study, HC58 DNA vaccinated goats were artificially infected with 5, 000 dose of infective H. contortus L 3 (third larval stage), and cellular immune responses and abomasum worm burden examined. The results showed that peripheral CD4+, CD8+ T and B lymphocytes for nematode challenged