PHD-Department of Zoologial Sciences
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Browsing PHD-Department of Zoologial Sciences by Subject "Burkitt's lymphoma --Nyanza, Kenya"
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Item Human dietary selenium deficiency as a risk factor in the pathogenesis of endemic burkitt's lymphoma in Nyanza(2012-04-24) Sumba, Peter Odada; Kabiru, E.W.; Orango, Alloys S.S.Endemic Burkitt lymphoma (eBL) has been associated with Epstein-Barr virus (EBY) and holoendemic Plasmodium falciparum malaria. However, recent eBL incidence maps showing more refined spatial clustering within malaria holoendemic areas, suggest that other risk factors may be involved in the etiology of eBL. Therefore, we hypothesized that the selenoprotein glutathione peroxidase (GPx), a surrogate of nutritional status known to regulate homornal, enzymatic pathways, viral mutations and virulence, is an important biomarker for eBL risk. The study measured plasma GPx, anthropometric markers of malnutrition, EBY viral loads and malaria parasitemia in children aged 1-9 years (n=258) from two Locations in Nyanza Province, Kenya with higher than expected and lower than expected incidence of eBL. The study participants were malaria asymptomatic children from the community. The level of GPX selenium was determined using BIOXYTECH® Plasma (pGPX) Enzyme ImmunoassaysTM. USA. Q-PCR was used to determine EBY loads after extracting the DNA from EDTA preserved blood. Malaria parasite densities were determined from smears stained in 4% Giemsa by counting parasites against 200 wbc and multiplying results by 40 for values per microliter of blood. The distribution range of pGPx selenium in the study area was 0.55 - 7.lmcgldL mean 2.88mcgldL (n=167). Children residing in eBL low risk clusters had higher mean GPx Se 3.767, SD1.570. The min-max (0.910 -7.1 OmcgldL) (n=66) and those living in eBL high risk areas had 2.308; SO 0.670; min-max GPx Se 0.589 - 3.330 mcgldL (n= 101), differences were significant at p