RP-Department of Zoological Sciences

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Browsing RP-Department of Zoological Sciences by Author "Agumbah, G J"

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    The effects of experimental Trypanosoma (Trypanozoon) (brucei) evansi infection on the fertility of male goats.
    (Veterinary Research Communications, 1991-02) Ngeranwa, J.J.N.; Mutiga, E R; Agumbah, G J; Gathumbi, Peter Karuri; Munyua, W K
    The effects on the fertility of small East African male goats of intravenous infection with Trypanosoma (t) (b) evansi were studied. Six infected bucks developed erratic, low but persistent parasitaemia, the packed cell volume dropped gradually but significantly (p less than 0.001) and they became emanciated. Half of these bucks developed clinical orchitis. Two bucks died of the disease during the experiment. Semen from all the infected bucks deteriorated in quality and quantity and those with clinical orchitis became totally aspermic. Spermatozoal abnormalities and the number of dead spermatozoa rose significantly. Later in the disease, the testicles of the infected bucks atrophied. Histologically, the testicles from the infected animals became devoid of spermatozoa, the testicular blood vessels contained microthrombi and there was infiltration of inflammatory cells. Subsequently, diffuse calcification set in, with calcium deposits obliterating most of the seminiferous vesicles and ducts and also the epididymal ducts.
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    Pathogenesis of Trypanosoma (brucei) evansi in small east African goats.
    (Research in Veterinary Science, 1993-05) Ngeranwa, J.J.N.; Gathumbi, Peter Karuri; Mutiga, E R; Agumbah, G J
    Trypanosoma evansi is the cause of surra, a camel disease which is the most important single cause of economic losses in camel rearing areas. Sheep and goats herded with camels are the most likely hosts for T evansi. Upon intravenous infections goats developed erratic parasitaemia, lost weight and their packed cell volume dropped significantly (P < 0.001). Trypanosomes were demonstrated by direct microscopy in extravascular locations such as synovial, peritoneal and cerebrospinal fluids and also in lymph by subinoculations into mice. The carcases were emaciated and pale. Histologically there was lymphatic tissue hyperplasia, muscular atrophy and nephrotic changes. Two animals had necrotic foci in the liver, kidneys, lymph nodes, spleen and lungs and also bronchopneumonia. Histologically there was depopulation of lymphocytes in lymphatic tissues, destruction of hepatocytes in the liver with infiltration by inflammatory cells in the liver, lymph nodes, spleen and the kidneys.