The dataset investigates the magnitude of the misinforma- tion content influencing scepticisms about the novel COVID- 19 pandemic in Africa. The data is collected via an electronic questionnaire method and twenty-one Africa countries ran- domly participated. Responses were received from all the five regions of Africa. The data is structured to identify some leading misinformation been propagated in the media. For data, in brief, we performed a descriptive analysis of the data and also examine the degree of each selected misinforma- tion contents on the immune perception of respondents us- ing Confirmatory Factor Analysis. Another research can use the dataset to investigate how misinformation and religion misconception promote ignorance about disease or pandemic in Africa or the dataset could serve as supplementary mate- rial for further investigation of COVID-19 pandemic in Africa.