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Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.

Were, T.; Davenport, G. C.; Yamo, EO; Hittner, James B.; Awandare, GA; Otieno, Micheal Frederick; Ouma, C; Orago, A. S.; Vulule, JM; Ong'echa, J. M.; Perkins, D. J. (Microbes and Infection, 2009)

Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, ...

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.

Ouma, C.; Davenport, G. C.; Were, T.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R. E.; Perkins, D. J. (Human Genetics, 2008-11)

Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

Ouma, C.; Keller, C.C.; Opondo, D.A.; Were, T.; Otieno, Richard O.; Otieno, Micheal Frederick; Orago, A. S.; Ong'echa, J. M.; Vulule, JM; Ferrell, RE; Perkins, D. J. (American Journal of Tropical Medicine and Hygiene, 2006-04)

A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.

Ouma, C.; Keller, C.C.; Davenport, G. C.; Were, T.; Konah, S.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R.E.; Perkins, D. J. (Infection and Immunity, 2010-01)

Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates ...