Parcourir RP-Department of Pathology par date de publication

Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

Ouma, C.; Keller, C.C.; Opondo, D.A.; Were, T.; Otieno, Richard O.; Otieno, Micheal Frederick; Orago, A. S.; Ong'echa, J. M.; Vulule, JM; Ferrell, RE; Perkins, D. J. (American Journal of Tropical Medicine and Hygiene, 2006-04)

Suppression of RANTES in children with Plasmodium falciparum malaria.

Were, T.; Hittner, James B.; Ouma, C.; Otieno, Richard O.; Orago, A. S.; Ong'echa, J. M.; Vulule, J. M.; Keller, C. C.; Perkins, D. J. (Haematologica, 2006-10)

Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated ...

Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis.

Thuita, John Kibuthu; Kagira, John Maina; Mwangangi, David Mumo; Matovu, E.; Turner, C. M.; Masiga, D. (Public Library of Science, 2008-05-14)

We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ...

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.

Ouma, C.; Davenport, G. C.; Were, T.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R. E.; Perkins, D. J. (Human Genetics, 2008-11)

Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.

Were, T.; Davenport, G. C.; Yamo, EO; Hittner, James B.; Awandare, GA; Otieno, Micheal Frederick; Ouma, C; Orago, A. S.; Vulule, JM; Ong'echa, J. M.; Perkins, D. J. (Microbes and Infection, 2009)

Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, ...

A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.

Ouma, C.; Keller, C.C.; Davenport, G. C.; Were, T.; Konah, S.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R.E.; Perkins, D. J. (Infection and Immunity, 2010-01)

Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates ...

Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

Were, T.; Gichuki, C.W.; Ong'echa, J. M.; Ouma, Collins; Anyona, S.B.; Kempaiah, P.; Raballah, E.; Davenport, G. C.; Konah, S.N.; Vulule, J.M.; Hittner, James B.; Perkins, D. J. (PubMed, 2011)

Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ...

Assessment of voiding function in inhabitants infected with Schistosoma haematobium.

Muhoho, ND; Watanabe, K; Mutua, WR; Kiliku, FM; Awazawa, T; Moji, Kazuhiko; Aoki, Y (Tropical Pediatrics, 2011-08)

Voiding function of Schistosoma haematobium infected students was evaluated in 45 schoolboys in Kwale district, Coast province, Kenya, using a questionnaire and uroflowmetry. Sixty-eight schoolboys who were S. haematobium ...

Tethered Cord Syndrome Secondary to the Unusual Constellation of a Split Cord Malformation, Lumbar Myelomeningocele, and Coexisting Neurenteric Cyst

Nzioka, A.; Okechi, H.; Albright, A.L. (Hindawi Publishing Corporation, 2012)

We describe a seminal case report of a child with a tethered cord syndrome secondary to the unusual constellation of a split cord malformation, lumbar myelomeningocele, and coexisting neurenteric cyst. A 17-year-old ...

Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria

Davenport, G. C.; Hittner, James B.; Were, T.; Ong'echa, J. M.; Perkins, D. J. (Wiley Periodicals, Inc., 2012)

Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater ...

Reduced interferon (IFN) –α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anaemia and longitudinal all-cause mortality

Were, T.; Kempaiah, P.; Anyona, S. B.; Raballah, E.; Davenport, G. C.; Hittner, James B.; Ong'echa, J. M.; Perkins, D. J. (PubMed, 2012-08)

Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ...

Incidence of perineural invasion in prostate adenocarcinoma: Rural Kenyan population experience

Nzioka, A.l.; Onyuma, T.; Gakinya, S. (Kenyatta University, 2014)

Introduction: Prostate cancer appears to be more aggressive amongst patients of African descent, a condition which could be associated with the presence of perineural invasion and higher Gleason scores of the ...

Health Seeking Behavior, Practices of TB and Access to Health Care among TB Patients in Machakos County, Kenya. A Cross-Sectional Study

Mutinda, Kasusu A.; Kabiru, Ephantus W.; Mwanik, Peter .K. (IISTE, 2014)

Despite efforts to implementation of the DOTS programme in Kenya since the year (1993) and achieving 100% coverage by the year 1996; new TB cases continue to emerge in communities, a significance of TB transmission. The ...

Cross-sectional Survey of Rift Valley Fever Virus Exposure in Bodhei Village Located in a Transitional Coastal Forest Habitat in Lamu County, Kenya.

Muiruri, S.; Kabiru, Ephantus W.; Muchiri, E. M.; Hussein, H.; Kagondu, F.; LaBeaud, A. D.; King, C. H. (American Society of Tropical Medicine and Hygiene, 2015)

Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in ...

Mammary analogue secretory carcinoma of the salivary gland of a recently described tumour: A case report

Nzioka, A.; Onyuma, P.; Gakinya, S. (Kenyatta University School of Medicine, 2015)

Mammary Analogue Secretory Carcinoma (MASC) is a recently described tumour of the salivary gland, characterized by the t (12; 15) (p13; q25) translocation. We report a case from a 40 year old female who presented with ...

Impact of sanitation improved school latrine on latrine-related practices, perceptions attitude and occurrence of diarrhoea in children in Mwea Division, Kirinyaga District, Central Kenya

Ng'ethe, Muhoho; Mitsui, Y.; Mwandawiro, C. (Kenyatta University School of Medicine, 2015)

Background: School latrines in Mwea irrigation regions are unsanitary and unhygienic. School children who are the end point users of the latrines are exposed to the unhygienic conditions of the latrines and are likely ...

Prevalence and Correlates of Alcohol Use among Underage High-School Students in Murang’a and Kajiado Counties, Kenya

Okwarah, Patrick; Gakunju, Richard; Kabiru, Ephantus; Malla, Lucas; Okedi, William; Mutham, Lawrence; Karanja, Simon (Researchjournali’s Journal of Public Health, 2015-07)

Background: Alcohol use during adolescence is an important risk factor for a host of physical and social problems affecting the young people globally. There is limited data on the prevalence of alcohol use among the ...

Expression of p53 and HER2/Neu in Kenyan Women with Primary Ovarian Carcinoma

Mutuiri, A.P.; Nzioka, A.; Busarla, S.V.; Sayed, S.; Moloo, Z. (Lippincott, Williams & Wilkins, 2016)

Ovarian carcinomas are a leading cause of cancer mortality among women. Two of the more commonly described markers of prognostic significance in primary ovarian carcinomas are p53 and HER2/neu. Overexpression of both markers ...

Schistosoma mansoni Infection Can Jeopardize the Duration of Protective Levels of Antibody Responses to Immunizations against Hepatitis B and Tetanus Toxoid

Riner, D. K.; Ndombi, E. M.; Carter, J. M.; Omondi, A.; Kittur, N.; Kavere, E.; Korir, H. K.; Flaherty, B.; Karanja, D.; Colley, D. G. (Public Library of Science, 2016)

Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China

Zhao, Jizi; Chen, Jie; Zhao, Ming; Qiu, Xiaohong; Chen, Xiaobei; Zhang, Wenli; Sun, Rui; Ogutu, James Opiyo; Zhang, Fengmin (National Institute of Infectious Diseases, 2016)