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Efficacy of Trypan: a Diminazene Based Drug as Antileishmanial Agent
(PubMed, 2004)
Trypan, a diamidine based drug, was tested as an antileishmanial agent. Duplicate cultures of both Leishmania major and Leishmania donovani promastigotes in M199 medium and Trypan at various concentrations were tested. The ...
Prevalence of Antibodies and Cell Mediated Immune Response against Leishmania Major in Feral Nonhuman Primates from Kenya.
(PubMed, 2009)
In Kenya, Leishmania major is responsible for human cutaneous leishmaniasis (CL). Natural infection with L. major of a vervet monkey and experimental susceptibility of some nonhuman primates (NHPs) from Kenya has been ...
Leishmania parasite specific CD4 + synergizes and correlates positively with CD8 + T cells in the production of gamma interferon foll owing immunization of the vervet monkey (Chlorocebus aethiops) model
(2013-03)
Although there is currently no vaccine against leishmaniasis in routine use anywhere in the world, cases of self cure in cutaneous leishmaniasis, accompanied by solid immunity to reinfection, make vaccine development a ...
A Review of Adjuvants for Leishmania Vaccine Candidates.
(PubMed, 2010)
Over the last decade, there has been a flurry of research on adjuvants for vaccines, and several novel adjuvants are now licensed products or in late stage clinical development. The success of adjuvants in enhancing the ...
Immunization with Leishmania Vaccine-Alum-Bf'G and Montanide ISA 720 Adjuvants Induces Low-Grade Type 2 Cytokines and High Levels of IgG2 Subclass Antibodies in the Vervet Monkey (Chlorocebus aethiops) Model
(Blackwell Publishing Ltd., 2012-07-29)
The availability of hundreds of adjuvants has prompted a need for identifying rational standards for the selection of adjuvant formulation based on sound immunological principles for human vaccines. As cytokines elaborated ...
In Vitro and in Vivo Antileishmanial Efficacy of a Combination Therapy of Diminazene and Artesunate against Leishmania Donovani in BALB/c Mice.
(PubMed, 2011)
The in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be ...
Safety and Skin Delayed-type Hypersensitivity Response in Vervet Monkeys Immunized with Leishmania Donovani Sonicate Antigen Delivered with Adjuvants
(Institute of Primate Research, 2013-01)
In this study, we report on the safety and skin delayed-type hypersensitivity (DTH), responses of the Leishmania donovani whole cell sonicate antigen delivered in conjunction with alum-BCG (AlBCG), Montanide ISA 720 (MISA) ...
Immunology of leishmaniasis
(2013-06)
Resolution of leishmanial infection is dependent on the coordinated interactions between components of cell mediated immune response, central to which is the activation of targeted T-cell populations for appropriate cytokine ...
