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Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya

Ochwedo, Kevin O.; Onyango, Shirley A.; Omondi, Collince J.; Orondo, Pauline W.; Ondeto, Benyl M.; Lee, Ming-Chieh; Atieli, Harrysone E.; Ogolla, Sidney O.; Githeko, Andrew K.; Otieno, Antony C. A.; Mukabana, Wolfgang R.; Yan, Guiyun; Zhong, Daibin; Kazura, James W. (PLOS ONE, 2022-04)

Background Leading transmission-blocking vaccine candidates such as Plasmodium falciparum surface protein 25 (Pfs25 gene) may undergo antigenic alterations which may render them ineffective or allele-specific. This study ...

Toxicity of Toddalia Asiatica is Associated with Microcephaly and Hypochondroplasia in Mice

Joseph, Gichuru M; Maina, Mwonjoria JK; David, Mburu N; Nelson, Menza C (www.phytopharmajournal.com, 2022)

In Kenya various plant extracts are widely used as folklore remedies for various ailments including malaria etc. However, use of these traditional remedies poses a risk to the users due to the scarcity of data on their ...

Lipid Profiles, Cardiovascular Disease Risk and Dyslipidemia in HIV Positive Patients on HAART at Machakos Level Five Hospital, Machakos County

Syengo, Sarah Malinda; Mutai, Brian Kipngetich; Menza, Nelson Chengo; Mathenge, Scholastica Gatwiri (Opast Publishing Group, 2023)

This study determined the lipid profiles, dyslipidemia and cardiovascular disease risk as well as their associated risk factors in patients who are positive for the human immunodeficiency virus on antiretrovirals. The ...

Human Papillomavirus Infection: Molecular Epidemiology and Acceptability of Screening and Vaccination among Women in Eastern Kenya Counties

Njue, James Kinoti; Muturi, Margaret W.; Kamau, Lucy; Muriuki, Joseph; Lwembe, Raphael (AJOL, 2021)

BACKGROUND Human Papillomavirus associated cervical cancer in Kenya caused 3,286 deaths where cervical screening rate was 3.2% in 2018. This study examined knowledge, attitudes, practices, and perceptions (KAPP) on ...

Determination of Sarcosine in Urine as a Predictor of Prostate Cancer Using Enzyme Linked Immunosorbent Method

Januaris, Mukaa M.; Njoroge, Wachuka Gathigia; Rado, Antony Omondi; Waweru, Jeremiah Gathirwa (JMR, 2023)

Prostate cancer is a type of malignancy that is defined by abnormal development of cells in the prostate tissue. Prostate cancer needs early intervention since its incidence and prevalence is high across the world leading ...

Extended-Spectrum β-Lactamase- Producing Gram-Negative Bacterial Infections in Severely Ill COVID-19 Patients Admitted in a National Referral Hospital, Kenya

Mutua, Jeniffer Munyiva; Mwaniki, John Njeru; Musyoki, Abednego Moki (Research Square, 2023)

Bacterial infections in COVID-19 patients, especially those caused by multidrug-resistant gram-negative strains, are associated with increased morbidity, hospital stay and mortality. However, there is limited data on the ...