Effects of Maalox Plus® Antacid and PureCal® Calcium Supplement on Physical Characteristics, Body Weight, Tissue Minerals and Histopathology of Rats Subjected to Alcohol Intoxication
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Date
2017-05
Authors
Onyango, T. O.
Mburu, D. N.
Ngugi, M. P.
Kamau, J. K.
Juma, K. K.
Journal Title
Journal ISSN
Volume Title
Publisher
OMICS International
Abstract
Overconsumption of alcohol is associated with morbidity including depletion of the body’s stores of magnesium
and calcium. Conversely therapy with magnesium (Mg) and calcium (Ca) in the event of chronic alcoholism
normalizes elevated enzyme activities. Similar information on acute alcohol intoxication is missing. This study
examined the effects of Maalox plus® antacid and pureCal® calcium supplement which are rich in Mg and Ca,
respectively, on the body weight, tissue magnesium and calcium together with histopathology of rats exposed to
acute alcohol intoxication. Alcohol was administered orally at a dosage 5 g/kg body weight for five days and
supplements for two days of the week for duration of 28 days. The animals were weighed weekly and tissues
obtained at the end of the treatment regimen. Statistical comparison was done using one way ANOVA followed by
Tukey’s test. Alcohol ingestion leads to hypomagnesemia a condition that was reversed by both drugs. Liver
histology showed that alcohol caused cellular infiltration and cytoplasmic vacuolization. For kidney there was cellular
infiltration and widening of tubules. Visible improvement of the liver histology architecture was discernible in rats cotreated
with Ca and Mg. These results showed that alcohol altered tissue architecture and the renal cation exchange
mechanism as shown by the variation in serum Ca2 and K levels. Maalox plus® and pureCal® alleviated the alcohol
induced adverse effects. These findings allude to these drugs being useful agents with potential applications in the
management of adverse effects associated with acute alcohol intoxication.
Description
Research Article
Keywords
Alcohol, Maalox plus, PureCal, Liver, Kidney
Citation
Onyango TO, Mburu DN, Ngugi MP, Kamau JK, Juma KK (2017) Effects of Maalox Plus® Antacid and PureCal® Calcium Supplement on Physical Characteristics, Body Weight, Tissue Minerals and Histopathology of Rats Subjected to Alcohol Intoxication. Clin Exp Pharmacol 7: 237. doi:10.4172/2161-1459.1000237