In vivo antidiabetic activity of aqueous and ethyl acetate leaf extract of Senna singuena (Delile) in alloxan induced diabetic mice
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Date
2017-06
Authors
Njogu, Stephen M.
Arika, W.M.
Machocho, Alex K.
Ngeranwa, J.J.N.
Njagi, Eliud N.M.
Journal Title
Journal ISSN
Volume Title
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Abstract
The folkloric claims that Senna singuena confers antidiabetic effect to prescribed patients has received long
term clinical application accompanied by limited scientific data in support of such claims. This study aimed at
bioscreening for hypoglycemic activity of the aqueous and organic fractions of S. singuena in alloxan induced
diabetic mice. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan
monohydrate followed by graded doses of the aqueous and ethyl acetate leaf extract administered to the
experimentally diabetic mice following an overnight fast. The composition of the various phytochemicals of
the plant extract was quantitatively assessed using standard procedures. Oral and intraperitoneal administration
of the aqueous and ethyl acetate leaf extract caused a significant reduction in plasma glucose level in a dose
independent manner in both fractions. The hypoglycemic activity could be attributed to phytoconstituents
found in the plant extract. The generated data supports the folkloric claims associating S. singuena with
hypoglycemic effects. However, there is need for further studies on this plant to investigate the mechanism of
its activity and determine its safety profiles in order to explore possibilities of developing a new antidiabetic
drug.
Keywords: Diabetes mellitus, Alloxan monohydrate, Oral and intraperitoneal, Antidiabetic, hypoglycemic, Sennasinguena.
Description
Keywords
Diabetes mellitus, Alloxan monohydrate, Oral and intraperitoneal, Antidiabetic, hypoglycemic, Senna singuena
Citation
The Journal of Phytopharmacology 2017; 6(2): 84-92, www.phytopharmajournal.com