Hassanali, AhmedOmole, R. A.Gathirwa, J.Akala, H.Malebo, H. M.Machocho, Alex K.Ndiege, I. O.2014-04-162014-04-162014-04-12Phytochemistry Available online 12 April 20141873-37000031-9422http://ir-library.ku.ac.ke/handle/123456789/9379http://dx.doi.org/10.1016/j.phytochem.2014.03.026From the leaves of Stephania abyssinica, three alkaloids were isolated: (−)-pseudocurine (1), (−)-pseudoisocurine (2) and (−)-10-oxoaknadinine (3). (−)-Pseudocurine and (-)-pseudoisocurine showed strong anti-plasmodial activity against both chloroquine-susceptible D6 and resistant strains of Plasmodium falciparum (IC50 0.29 ± 0.00 and 0.31 ± 0.01 μg/ml, respectively) while (−)-pseudoisocurine exhibited moderate and mild activity (0.75 ± 0.11 and 1.65 ± 0.03 μg/ml).enMenispermerceaeStephania abyssinicaAlkaloidsBisbenzylisoquinoline(−)-Pseudocurine and (−)-pseudoisocurineHasubanane(−)-10-oxoaknadinine anti-plasmodial activityArticle