Gichui, W. G.Mwonjoria, J. K.Waweru, F. N.Kariuki, H. N.2017-09-042017-09-042017International Journal of Phytopharmacology. 8(3), 2017, 112-116.0975 – 93282229 – 7472http://ir-library.ku.ac.ke/handle/123456789/17773http://www.onlineijp.com/download.php?id=423&f=149735041716_onlineijp.pdfResearch ArticleThe use of plant parts for a wide range of therapeutic purposes is commonly practiced in Africa where several plants are used as folklore remedies for fever, inflammation and pain. An example of plants whose parts are used for analgesia is Croton Megalo carpus however; scientific studies have not been done to evaluate the efficacy of the claimed antinociceptive activity. The aim of this study was to evaluate the antinociceptive activity of the stem, root bark and leaves extract using animal model. The antinociceptive activity was investigated using the chemical pain test models; writhing and the formalin tests as well as one thermal pain test model (tail Flick test). In all test, the extract exhibited highly significant (p < 0.001) antinociceptive effects. These results showed that the extracts of C. megalocarpus exhibited peripheral, inflammatory and central antinociceptive activity. Hence it probably contains phytochemicals that may be of value in development of a novel remedy for analgesia. However, further studies need to be done to elucidate nature and mechanism(s) of action of these metabolites.enCroton megalocarpusAntinociceptiveTail flickFormalinPainWrithingAnalgesicArticle