Ndiege, Isaiah OLwande, WilberAkenga, Teresa OMahanga, Geoffrey M.2015-02-102015-02-102005Journal Home Vol 19, No 1 (2005)http://ir-library.ku.ac.ke/handle/123456789/121982-Hydroxy-4-methoxybenzaldehyde (1), a compound isolated from Mondia whytei (Hook) Skeels (Asclepiaceae) roots exhibited larvicidal activity (LD5022 mg/mL). A total of 18 other derivatives and closely related congeners revealed varying levels of larvicidal activity. Several closely related congeners, like 2-benzyloxy-4-methoxybenzaldehyde (2), 2-hydroxybenzaldehyde (12), 2-benzyloxybenzaldehyde (3) and benzylphenyl ether (4), showed marked improvement in activity (LD5010, 9, 4.8, 1.2 mg/mL, respectively) against Anopheles gambiae larvae. 2-Benzoyloxy-4-methoxybenzaldehyde (5) exhibited similar activity level (LD50 28 mg/mL) as 1.en2-Hydroxy-4-methoxybenzaldehyde,Larvicides,Structure-activity relationships,2-Hdroxybenzaldehyde,2-Benzyloxybenzaldehyde,Benzylphenyl ether Anopheles gambiae,Article