In vitro antifungal activity of leaf extracts from aloe secundiflora, bulbine frutescens, vernonia lasiopus and tagetes minuta against Candida albicans.
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Date
2016-01
Authors
Rachuonyo, H.O.
Gatheri, G.W.
Ogola, P.E.
Arika, W.M.
Wambani, J.R.
Kebira, A.N.
Kamau, D.N.
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Abstract
Crude leaf extracts from medicinal plants were screened for in vitro antifungal properties against clinical isolate of
Candida albicans. The antifungal test was carried out using the Kirby Bauer method. All the extracts from the plants
tested showed antifungal activity against clinical isolate of Candida albicans with the extract from Vernonia lasiopus
being more active as compared to the others. The minimum inhibitory concentration ranged from 4.0 to 8.9 mg/ml.
The standard antifungal used as positive control was fluconazole (15 μg/ml) whereas dimethyl sulphoxide and distilled
water were used as negative control. Preliminary screening for the presence of phytochemicals was also done to
determine if there was presence of any, flavonoids, saponins, tannins and alkaloids.
Description
http://dx.doi.org/10.4172/2167-0412.1000229
Keywords
Candida albicans, Phytochemicals, Fluconazole, Dimethyl sulphoxide
Citation
Medicinal & Aromatic Plants, 2016, Vol.5, iss.2 http://dx.doi.org/10.4172/2167-0412.1000229