• English
    • français
  • English 
    • English
    • français
  • Login
View Item 
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Health Sciences
  • RP-Department of Pre-clinical Sciences
  • View Item
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Health Sciences
  • RP-Department of Pre-clinical Sciences
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Distinct Pattern of Class and Subclass Antibodies in Immune Complexes of Children with Cerebral Malaria and Severe Malarial Anaemia.

Thumbnail
View/Open
Full Text Article (97.20Kb)
Date
2008
Author
Mibei, Erick Kipsang
Otieno, W. O.
Orago, A. S.
Stoute, J. A.
Metadata
Show full item record
Abstract
Plasmodium falciparum infection can lead to deadly complications such as severe malaria-associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes (ICs). To further investigate the quantitative differences in antibody class/subclass components of ICs in SMA and CM, we enrolled 75 children with SMA and 32 children with CM from hospitals in western Kenya and matched them to 74 and 52 control children, respectively, with uncomplicated symptomatic malaria. Total IgG IC levels were always elevated in children with malaria upon enrollment, but children with CM had the highest levels of any group. Conditional logistic regression showed a borderline association between IgG4-containing IC levels and increased risk of SMA (OR = 3.11, 95% CI 1.01-9.56, P = 0.05). Total IgG ICs (OR = 2.84, 95% CI 1.08-7.46, P = 0.03) and IgE-containing ICs (OR = 6.82, OR 1.88-24.73, P < or = 0.01) were associated with increased risk of CM. These results point to differences in the contribution of the different antibody class and subclass components of ICs to the pathogenesis of SMA and CM and give insight into potential mechanisms of disease.
URI
http://ir-library.ku.ac.ke/handle/123456789/8553
Collections
  • RP-Department of Pre-clinical Sciences [4]

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback

 

 

Browse

All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback