Browsing RP-Deparment of Medical Laboratory Sciences by Author "Gachara, George"
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Characterization of occult hepatitis B in highrisk populations in Kenya
Kiptoon, Beatrice Jepkemei; Missiani, Ochwoto; Swidinsky, Ken; Day, Jacqueline; Gebrebrhan, Henok; McKinnon, Lyle R.; Andonov, Anton; Oyugi, Julius; Kimani, Joshua; Gachara, George; Songok, Elijah Maritim; Osiowy, Carla (PLOS ONE, 2020)Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the liver or serum in the absence of detectable HBV surface antigen (HBsAg). OBI poses a risk for the development of cirrhosis ... -
Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon
Gachara, George; Magoro, Tshifhiwa; Mavhandu, Lufuno; Lum, Emmaculate; Kimbi, Helen K.; Ndip, Roland N.; Bessong, Pascal O. (BioMed Central, 2017)Purpose: Occult hepatitis B infection (OBI) among HIV positive patients varies widely in different geographic regions. We undertook a study to determine the prevalence of occult hepatitis B infection among HIV infected ... -
Evolutionary Pattern of the Hemagglutinin Gene of Influenza B Viruses Isolated in Kenya 2005-2009
Gachara, George; Bulimo, W.; Magana, J.; Simwa, J.; Symekher, S. (African Journal of Health Sciences, 2011-06-17)Background: In humans, the inability to provide lasting protection against influenza B virus infection is due, in part, to the rapid evolution of the viral surface glycoprotein, haemagglutinin (HA), which leads to a change ... -
Human Bocavirus Infection in Children with Acute Respiratory Infection in Nairobi, Kenya
Gachara, George; Symekher, S.L.; Simwa, J.; Gichogo, J.; Rotich, M.; Ng’ayo, M.O.; Magana, J. (Scientific Research Publishing, 2013-12)Background: Acute respiratory infection (ARI) is a leading cause of morbidity and mortality in children under five years of age in developing countries with viruses contributing significantly to this problem. The recently ... -
Potency status of oral polio virus vaccine among retrieved field samples in Kenya
Gachara, George; Hassan, J. A.; Mbugua, F.; Muchiri, J.; Symekhah, S.; Nakitari, G.; Borus, P.; Kamau, T.; Kombich, J. (Elsevier, 2014-04)Background: In 1988 the World Health Organization (WHO) proposed mass immunization campaigns with the trivalent oral polio vaccine (TOPV) among children less than 5 years of age. The Vaccine Vial Monitor (VVM) is a small ... -
Seroprevalence and Genotypic Characterization of HBV among Low Risk Voluntary Blood Donors in Nairobi, Kenya
Aluora, Patrick Okoti; Muturi, Margaret Wangui; Gachara, George (Springer Nature, 2020)Background: Hepatitis B virus (HBV) causes signifcant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver cirrhosis and hepatocellular carcinoma. The Kenya National Blood Transfusion ... -
Serotype and Genetic Diversity of Human Rhinovirus Strains that Circulated in Kenya in 2008
Milanoi, Sylvia; Ongus, Juliette R.; Gachara, George; Coldren, Rodney; Bulimo, Wallace (Wiley Open Access, 2016)Background: Human Rhinoviruses (HRVs) are a well-established cause of the common cold and recent studies indicated that they may be associated with severe acute respiratory illnesses (SARIs) like pneumonia, asthma and ... -
Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic
Gachara, George; Symekher, S.; Otieno, M.; Magana, J.; Opot, B.; Bulimo, W. (Elsevier, 2016)An influenza pandemic caused by a novel influenza virus A(H1N1)pdm09 spread worldwide in 2009 and is estimated to have caused between 151,700 and 575,400 deaths globally.Whilewhole genome data on newvirus enables a deeper ...