Browsing RP-Deparment of Medical Laboratory Sciences by Issue Date
Now showing items 1-20 of 36
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Immunization of Mice and Baboons with the Recombinant Sm28GST Affects Both Worm Viability and Fecundity after Experimental Infection with Schistosoma Mansoni.
(PubMed, 1991-09)A member of the glutathione S-transferase family, Sm28GST has previously demonstrated a good ability to protect rodents against experimental infection with Schistosoma mansoni. In order to evaluate its efficacy in a model ... -
Combining Evidence of Natural Selection with Association Analysis Increases Power to Tetect Malaria-Resistance Variants.
(PubMed, 2007)Statistical power to detect disease variants can be increased by weighting candidates by their evidence of natural selection. To demonstrate that this theoretical idea works in practice, we performed an association study ... -
Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production
(PubMed, 2008-10)Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ... -
Prevalence and Antimicrobial Susceptibility of Enterobacteriaceae Collected from Patients with Wounds at Kenyatta National Hospital
(2009)Prevalence and sensitivity trends of Enterobacteriaceae isolated from septic wounds were determined through a prospective cross sectional study. One hundred and fifteen specimens isolated from in-patients in the Department ... -
Evolutionary Pattern of the Hemagglutinin Gene of Influenza B Viruses Isolated in Kenya 2005-2009
(African Journal of Health Sciences, 2011-06-17)Background: In humans, the inability to provide lasting protection against influenza B virus infection is due, in part, to the rapid evolution of the viral surface glycoprotein, haemagglutinin (HA), which leads to a change ... -
Identification and Susceptibility Profile of Vaginal Candida Species to Antifungal Agents among Pregnant Women Attending the Antenatal Clinic of Thika District Hospital, Kenya
(Scientific Research Publishing, 2013)Fungal infections have emerged as a world-wide health care problem in recent years, owing to the extensive use of broad-spectrum antibiotics. We screened 104 pregnant women with symptoms of vaginal candidiasis in the ... -
Human Bocavirus Infection in Children with Acute Respiratory Infection in Nairobi, Kenya
(Scientific Research Publishing, 2013-12)Background: Acute respiratory infection (ARI) is a leading cause of morbidity and mortality in children under five years of age in developing countries with viruses contributing significantly to this problem. The recently ... -
HIV type 1 drug resistance patterns among patients failing first and second line antiretroviral therapy in Nairobi, Kenya
(BioMed Central, 2014)Background: The ever-expanding rollout of antiretroviral therapy in poor resource settings without routine virological monitoring has been accompanied with development of drug resistance that has resulted in limited treatment ... -
Burden of Human Rhinovirus Infections in Influenza like Illnesses in Kenya
(Elsevier, 2014)Background: There have been several recent reports of respiratory outbreaks with associated mortality due to human rhinovirus (HRV) infection. Studies on viral etiologies of Influenza-like illness have shown that many ... -
Coagulation Factors Level in Fresh Frozen Plasma in Rwanda
(Kenya Medical Association, 2014)Objectives: To determine the level of coagulation factors and inherited inhibitors in Fresh Frozen Plasma (FFP) and to evaluate Prothrombin Time and activated partial thrombin time in fresh frozen plasma. Design: ... -
Potency status of oral polio virus vaccine among retrieved field samples in Kenya
(Elsevier, 2014-04)Background: In 1988 the World Health Organization (WHO) proposed mass immunization campaigns with the trivalent oral polio vaccine (TOPV) among children less than 5 years of age. The Vaccine Vial Monitor (VVM) is a small ... -
Non-Hepatic Adverse Effects of Antiretroviral Therapy for HIV Treatment and Care
(Adis, Springer Healthcare, 2016)High-level viral replication occurs when HIV enters the body. Due to frequent mutations, the virus becomes resistant in the body and persists in memory T cells making it incurable. Lifelong therapy is then required ... -
Oil Contents and Aflatoxin Levels in Peanuts Varieties Produced in Busia and Kisii Central Districts, Kenya
(OMICS International, 2016)Busia and Kisii Central districts have repeatedly reported high levels of aflatoxins in foods. The objectives of the study were to determine oil contents and the relationship between oil contents and the levels of total ... -
Serotype and Genetic Diversity of Human Rhinovirus Strains that Circulated in Kenya in 2008
(Wiley Open Access, 2016)Background: Human Rhinoviruses (HRVs) are a well-established cause of the common cold and recent studies indicated that they may be associated with severe acute respiratory illnesses (SARIs) like pneumonia, asthma and ... -
Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic
(Elsevier, 2016)An influenza pandemic caused by a novel influenza virus A(H1N1)pdm09 spread worldwide in 2009 and is estimated to have caused between 151,700 and 575,400 deaths globally.Whilewhole genome data on newvirus enables a deeper ... -
Characterization of occult hepatitis B virus infection among HIV positive patients in Cameroon
(BioMed Central, 2017)Purpose: Occult hepatitis B infection (OBI) among HIV positive patients varies widely in different geographic regions. We undertook a study to determine the prevalence of occult hepatitis B infection among HIV infected ... -
Occurrence of Aflatoxigenic Aspergillus Species in Various Varieties of Peanuts Produced in Western Kenya
(PrePrints, 2017)Aflatoxin contaminates foods including peanuts. Aflatoxin is a carcinogenic toxin mainly produced bty Aspergillus flavus. Other Aspergillus species that rarely produce aflatoxins are A. nomius and A. niger. Aflatoxin is ... -
Socio-demographic and sexual practices associated with HIV infection in Kenyan injection and non-injection drug users
(BioMed Central, 2018)Background: Substance use is increasingly becoming prevalent on the African continent, fueling the spread of HIV infection. Although socio-demographic factors influence substance consumption and risk of HIV infection, ... -
Seroprevalence of Cytomegalovirus Infection and Associated Risk Factors among Human Immunodeficiency Virus Infected Patients Attending Thika Level 5 Hospital, Kenya
(Scientific Research Publishing, 2018)Cytomegalovirus (CMV) is an important pathogen in immunocompromised individuals. Coupled with Human Immunodeficiency Virus (HIV), it causes end organ diseases leading to increased morbidity and mortality in the population. ... -
Occurrence of Aflatoxigenic Aspergillus Species in Peanut Varieties in Busia and Kisii Central Districts, Kenya
(Scientific Research Publishing, 2018)Recent studies have shown that peanuts in Kenya are highly contaminated with aflatoxins, however, information gaps exist on the characterization of the Aspergillus species that produce aflatoxins. Therefore, this gap ...
