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Urinary soluble egg antigen levels in Schistosoma haematobium infection in relation to sex and age of Kenyan schoolchildren following praziquantel treatment

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Date
2009-10
Author
Kihara, Jimmy H.
Njagi, E.N.M.
Kenya, E.U.
Mwanje, Marium T.
Odek, Adel E.
Govert, van Dam
Kahama, Anthony I.
Ouma, J. H.
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Abstract
Schistosoma haematobium soluble egg antigen (SEA) secreted in urine can be assayed to determine egg tissue load and hence morbidity in infected individuals. A cohort of 158 infected children aged 4–18 years was followed-up for 33 days pre and post treatment with a single dose of praziquantel. There was a significant difference in the prevalence of S. haematobium between males and females (P < 0.05). There were also significant differences in egg counts between age group ≤5 years compared with 6–8 years, 9–11 years and 12–14 years, and age group ≥15 years compared with 6–8 years, 9–11 years and 12–14 years (P < 0.05). Comparison of SEA among age groups indicated a significant difference between age group ≤5 years compared with 9–11 years, 12–14 years and ≥15 years, and age group ≥15 years compared with 9–11 years and 12–14 years (P < 0.05). There was a statistically significant correlation between levels of SEA and egg output (r2=0.961, P=0.010). These results are useful in the development of a SEA-based dipstick assay for field diagnosis of urinary schistosomiasis.
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http://ir-library.ku.ac.ke/handle/123456789/5931
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