• Login
    View Item 
    •   Repository Home
    • Research Papers (RP)
    • RP-School of Pure and Applied Sciences
    • RP-Department of Plant and Microbial Sciences
    • View Item
    •   Repository Home
    • Research Papers (RP)
    • RP-School of Pure and Applied Sciences
    • RP-Department of Plant and Microbial Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Antifungal, antibacterial and antimycobacterial activity of Entada abysinnica Steudel ex A. Rich (Fabaceae) methanol extract

    Thumbnail
    View/Open
    abstract (5.586Kb)
    Date
    2010-06-02
    Author
    Okemo, P. O.
    Mariita, Richard M.
    Orodho, John Aluko
    Mbugua, P. K.
    Metadata
    Show full item record
    Abstract
    The purpose of the study was to investigate the antifungal, antibacterial and antimycobacterial properties of methanol extract of Entada abysinnica steudel ex. A. Rich (Fabaceae) leaves used by herbalists from the Lake Victoria region, Kenya. The extract was tested against four strains of mycobacteria (Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum, and Mycobacterium smegmatis) using BACTEC Mycobacteria Growth Indicator Tube (MGIT) 960 system and the proportional method. Standard procedures were used to determine the zones of inhibition, minimum inhibitory concentrations (MICs) and minimum bactericidal/fungicidal concentrations (MBCs/MFCs) for Candida albicans, Salmonella typhi, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. The extract showed activity against some mycobacteria strains, especially M. tuberculosis. It also showed strong antimicrobial activity (zones of inhibition were between 9.00 and 14.10 mm) against C. albicans, Sa. typhi, and St. aureus. The extract gave a better zone of inhibition against C. albicans than fluconazole whose zone of inhibition was 13.00 mm. The MICs and MBCs for C. albicans and Sa. typhi were good. The crude extracts were also analyzed for the presence of phytochemicals. Phytochemical screening indicated that the extract most abundantly contained tannins, saponins, and flavonoids. The data suggest that the methanolic leaves extract of E. abysinnica could be a rich source of antimicrobial agents, especially antifungals. The results further show that there is some merit in the use of the plant in alternative medical practices. However, bioassays of isolated compounds are underway and will be reported during subsequent communications.
    URI
    http://ir-library.ku.ac.ke/handle/123456789/5803
    available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141308/
    Collections
    • RP-Department of Plant and Microbial Sciences [252]

    Designed by Library ICT Team copyright © 2017 
    Contact Us | Send Feedback

     

     

    Browse

    All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Designed by Library ICT Team copyright © 2017 
    Contact Us | Send Feedback