Search
Now showing items 1-10 of 10
Complement utilization in children with severe plasmodium falciparum malaria
(2011-08-23)
Complement system, an important component of the innate and adaptive immunity, is over activated during malaria infection. As a result, components of the cascade are utilized consumed and this has the potential to impair ...
Pyridoxal kinase activity in plasmodium falciparum and plasmodium berghei in vitro
(2012-06-11)
Pyridoxal kinase (PLK: EC2.7.1.35) is an essential enzyme for cellular synthesis of proteins where it plays a central role in transamination reactions. PLK is required for biosynthesis of B-6 coenzyme in which it ...
The expression of LFA-1, MAC-1 and ICAM-1 on leucocytes from patients with uncomplicated and those with complicated plasmodium falciparum malaria
(2012-02-02)
Malaria is a major cause of morbidity and mortality in sub-Saharan Africa. Most of the mortality is the result of severe infections that occur in a small proportion of individuals, mostly children and pregnant women. A ...
Prevalence of glucose-6- phosphate dehydrogenase deficiency in children enrolled in a malaria vaccine clinical trial in Western Kenya
(2012-02-10)
Deficiency of Glucose-6-phosphate dehydrogenase (G6PD) is the most frequently encountered genetic abnormality of red blood cell (RBC) metabolism, and is estimated to affect over 200 million people worldwide. Malaria is ...
Evalutation of malaria infection in relation to age, residence and diagnosis of patients attending Kipsamoite dispendary, Nandi North District, Kenya
(2012-02-23)
Malaria imposes a huge burden upon the health and economic development of tropical nations and has been identified as a major obstacle to sustainable development by the world's poorest regions. Diagnosis of malaria still ...
Single-dose pharmacokinetics of anti-malarial chlorproguanil and its active metabolite chlorcycloguanil in healthy adult volunteers
(2012-05-25)
Malaria, often referred to as "the King of Diseases", is the single largest cause of disease and death every year in tropical countries. It is possible to prevent malaria infections if those concerned (travelers to, and ...
Clinical evaluation of flourescent in- situ hybridization (Fish) assay for malaria diagnosis
(2012-11-29)
Giemsa microscopy has played a major role in malaria control as a standard or reference method in diagnosis. However, this technique has varied performance characteristics while other techniques are more expensive. As a ...
Prophylactic Activity of Hiv-Protease Inhibitors Against Malaria and Their Interaction with Antimalarial in Male Mice
(Kenyatta University, 2019-10)
Malaria and HIV/AIDS have a wide geographical overlap in several tropical regions. This makes co-infection of the two diseases very common. Due to enhanced global coverage of antiretroviral drugs (ARVs), HIV/AIDS patients ...
Comparison of Malaria Rapid Diagnostic Tests at Health Facilities and Community Level in Siaya County Kenya
(Kenyatta University, 2019-12)
Malaria remains a major public health problem affecting an estimated 40% of the world’s population and resulting in more than 650,000 deaths worldwide every year. The emergence and rapid spread of parasite resistance to ...
Antiplasmodial Activities and In Vivo Safety of Extracts and Compounds of Seven Indigenous Kenyan Medicinal Plants Used Traditionally to Treat Malaria
(Kenyatta University, 2020-10)
Among human parasitic diseases, malaria is the most important and it has global incidence of 300 to 500 million cases per year with about 1.5 million deaths among African children. Recently the disease has been subjected ...