RP-Department of Pathology
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Recent Submissions
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Effect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.
(Wiley Online Library, 2018)This study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross-sectional study ... -
Drug Susceptibility Profiles of Pulmonary Mycobacterium Tuberculosis Isolates From Patients in Informal Urban Settlements in Nairobi, Kenya
(2016)Background: Anti-tuberculosis drug resistance is an emerging health problem in Kenya and especially in slums. Slum environments create a conducive environment for the spread of tuberculosis (TB) due to high population density ... -
Warburgia Ugandensis: A Potent in Vivo Phytomedicine Against Plasmodium Knowlesi
(Journal of Pharmacognosy and Phytochemistry, 2020)Resistance to artemisinin-based therapies by Plasmodium falciparum and the entry of P. knowlesi as the fifth human malaria parasite present an urgent need for development of safe, affordable and effective therapeutic ... -
Young Adults in Endemic Areas: An Untreated Group In Need of School-Based Preventive Chemotherapy For Schistosomiasis Control and Elimination
(PubMed Central, 2018)Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students ... -
Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors
(Pubmed Central, 2020)RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral ... -
Health Seeking Behavior, Practices of TB and Access to Health Care among TB Patients in Machakos County, Kenya. A Cross-Sectional Study
(IISTE, 2014)Despite efforts to implementation of the DOTS programme in Kenya since the year (1993) and achieving 100% coverage by the year 1996; new TB cases continue to emerge in communities, a significance of TB transmission. The ... -
Prevalence and Correlates of Alcohol Use among Underage High-School Students in Murang’a and Kajiado Counties, Kenya
(Researchjournali’s Journal of Public Health, 2015-07)Background: Alcohol use during adolescence is an important risk factor for a host of physical and social problems affecting the young people globally. There is limited data on the prevalence of alcohol use among the ... -
HIV Prevalence among Secondary School Student Blood Donors in Nairobi County, Kenya
(International Journal of Science and Research (IJSR), 2018-07)The Human Immune deficiency Virus and the Acquired Immune Deficiency Syndrome situation in Kenya has affected blood collection in the country leading to a decline from 150,000 units to about 70,000 units annually, yet the ... -
Management of Type 2 Diabetes Mellitus by Diabetic Clients In Nyandarua South Sub –County, Kenya
(IPRJB, 2017)Purpose: Type 2 diabetes mellitus, (T2DM) is the most common form of diabetes, characterized by disorders of insulin resistance, insulin secretion, obesity, lipid abnormalities, hypertension, and cardiovascular diseases. ... -
The Demographic Characteristics of Mothers and their Compliance Levels with Infant and Young Child Feeding Recommendations in Nakuru Municipality, Kenya
(Academic Journals, 2017-07)Universally, optimal IYCF key indicators are low and current IYCF practices remain far from recommended levels. In Kenya, the National IYCF strategy recommends that infants should be exclusively breast fed for the first ... -
Socio-Demographic, Social economic and Socio-Cultural Factors that Influences Uptake of Cervical Cancer Screening Services in Low Resource Settings
(IPRJB, 2017)Background: Cervical cancer is the fourth commonest cancer in women and the seventh overall, with estimated 528,000 new cases every year. Around 85% of the global burden occurs in the low resource settings where it ... -
Effects of Female Genital Schistosomiasis in Reproductive Tract of Women Attending Kwale Hospital in Kwale County, Kenya
(International Journal of TROPICAL DISEASE & Health, 2017-06-17)Background: Female genital Schistosomiasis (FGS) caused by Schistosoma haematobium is a significant public health problem among women living in endemic areas. An estimated 45 million women in sub-Saharan Africa are ... -
Atypical Cervical Cytomorphologic Predictors: a Descriptive Study of Pre-Cervical Cancer Patients of Low Education in Kenya
(The Pan African Medical Journal, 2019)Introduction: high risk HPV is the perpetrator of cervical cancer disease, however screening and vaccination is not included in cervical cancer prevention program within public hospitals in Kenya. This descriptive study ... -
Determinants of Disclosure on HIV Sero-Status among People Living With HIV and on Antiretroviral Treatment at Mombasa County Referral Hospital, Kenya
(EPRA International Journal of Research and Development (IJRD), 2020)It is estimated that Kenya has 1.6 million people living with HIV and 88,000 new adult infections annually. The objective of this study was to explore the level of HIV sero – status disclosure and the disclosure outcomes ... -
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
(Elsevier, 2019)The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed ...
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Effect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.
(Wiley Online Library, 2018)This study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross-sectional study ... -
Drug Susceptibility Profiles of Pulmonary Mycobacterium Tuberculosis Isolates From Patients in Informal Urban Settlements in Nairobi, Kenya
(2016)Background: Anti-tuberculosis drug resistance is an emerging health problem in Kenya and especially in slums. Slum environments create a conducive environment for the spread of tuberculosis (TB) due to high population density ... -
Warburgia Ugandensis: A Potent in Vivo Phytomedicine Against Plasmodium Knowlesi
(Journal of Pharmacognosy and Phytochemistry, 2020)Resistance to artemisinin-based therapies by Plasmodium falciparum and the entry of P. knowlesi as the fifth human malaria parasite present an urgent need for development of safe, affordable and effective therapeutic ... -
Young Adults in Endemic Areas: An Untreated Group In Need of School-Based Preventive Chemotherapy For Schistosomiasis Control and Elimination
(PubMed Central, 2018)Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students ... -
Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors
(Pubmed Central, 2020)RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral ... -
Prevalence and Correlates of Alcohol Use among Underage High-School Students in Murang’a and Kajiado Counties, Kenya
(Researchjournali’s Journal of Public Health, 2015-07)Background: Alcohol use during adolescence is an important risk factor for a host of physical and social problems affecting the young people globally. There is limited data on the prevalence of alcohol use among the ... -
Health Seeking Behavior, Practices of TB and Access to Health Care among TB Patients in Machakos County, Kenya. A Cross-Sectional Study
(IISTE, 2014)Despite efforts to implementation of the DOTS programme in Kenya since the year (1993) and achieving 100% coverage by the year 1996; new TB cases continue to emerge in communities, a significance of TB transmission. The ... -
HIV Prevalence among Secondary School Student Blood Donors in Nairobi County, Kenya
(International Journal of Science and Research (IJSR), 2018-07)The Human Immune deficiency Virus and the Acquired Immune Deficiency Syndrome situation in Kenya has affected blood collection in the country leading to a decline from 150,000 units to about 70,000 units annually, yet the ... -
Management of Type 2 Diabetes Mellitus by Diabetic Clients In Nyandarua South Sub –County, Kenya
(IPRJB, 2017)Purpose: Type 2 diabetes mellitus, (T2DM) is the most common form of diabetes, characterized by disorders of insulin resistance, insulin secretion, obesity, lipid abnormalities, hypertension, and cardiovascular diseases. ... -
The Demographic Characteristics of Mothers and their Compliance Levels with Infant and Young Child Feeding Recommendations in Nakuru Municipality, Kenya
(Academic Journals, 2017-07)Universally, optimal IYCF key indicators are low and current IYCF practices remain far from recommended levels. In Kenya, the National IYCF strategy recommends that infants should be exclusively breast fed for the first ... -
Socio-Demographic, Social economic and Socio-Cultural Factors that Influences Uptake of Cervical Cancer Screening Services in Low Resource Settings
(IPRJB, 2017)Background: Cervical cancer is the fourth commonest cancer in women and the seventh overall, with estimated 528,000 new cases every year. Around 85% of the global burden occurs in the low resource settings where it ... -
Effects of Female Genital Schistosomiasis in Reproductive Tract of Women Attending Kwale Hospital in Kwale County, Kenya
(International Journal of TROPICAL DISEASE & Health, 2017-06-17)Background: Female genital Schistosomiasis (FGS) caused by Schistosoma haematobium is a significant public health problem among women living in endemic areas. An estimated 45 million women in sub-Saharan Africa are ... -
Atypical Cervical Cytomorphologic Predictors: a Descriptive Study of Pre-Cervical Cancer Patients of Low Education in Kenya
(The Pan African Medical Journal, 2019)Introduction: high risk HPV is the perpetrator of cervical cancer disease, however screening and vaccination is not included in cervical cancer prevention program within public hospitals in Kenya. This descriptive study ... -
Determinants of Disclosure on HIV Sero-Status among People Living With HIV and on Antiretroviral Treatment at Mombasa County Referral Hospital, Kenya
(EPRA International Journal of Research and Development (IJRD), 2020)It is estimated that Kenya has 1.6 million people living with HIV and 88,000 new adult infections annually. The objective of this study was to explore the level of HIV sero – status disclosure and the disclosure outcomes ... -
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
(Elsevier, 2019)The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed ... -
Functional Studies of T Regulatory Lymphocytes in Human Schistosomiasis in Western Kenya
(The American Journal of Tropical Medicine and Hygiene, 2018)Immunoregulation is considered a common feature of Schistosoma mansoni infections, and elevated levels of T regulatory (Treg) lymphocytes have been reported during chronic human schistosomiasis. We now report that the ... -
Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China
(National Institute of Infectious Diseases, 2016) -
Expression of p53 and HER2/Neu in Kenyan Women with Primary Ovarian Carcinoma
(Lippincott, Williams & Wilkins, 2016)Ovarian carcinomas are a leading cause of cancer mortality among women. Two of the more commonly described markers of prognostic significance in primary ovarian carcinomas are p53 and HER2/neu. Overexpression of both markers ... -
Cross-sectional Survey of Rift Valley Fever Virus Exposure in Bodhei Village Located in a Transitional Coastal Forest Habitat in Lamu County, Kenya.
(American Society of Tropical Medicine and Hygiene, 2015)Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in ...
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