Browsing RP-Department of Pathology by Title
Now showing items 24-34 of 34
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Reduced interferon (IFN) –α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anaemia and longitudinal all-cause mortality
(PubMed, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria
(Wiley Periodicals, Inc., 2012)Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater ... -
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
(Elsevier, 2019)The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed ... -
Socio-Demographic, Social economic and Socio-Cultural Factors that Influences Uptake of Cervical Cancer Screening Services in Low Resource Settings
(IPRJB, 2017)Background: Cervical cancer is the fourth commonest cancer in women and the seventh overall, with estimated 528,000 new cases every year. Around 85% of the global burden occurs in the low resource settings where it ... -
Suppression of RANTES in children with Plasmodium falciparum malaria.
(Haematologica, 2006-10)Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated ... -
Tethered Cord Syndrome Secondary to the Unusual Constellation of a Split Cord Malformation, Lumbar Myelomeningocele, and Coexisting Neurenteric Cyst
(Hindawi Publishing Corporation, 2012)We describe a seminal case report of a child with a tethered cord syndrome secondary to the unusual constellation of a split cord malformation, lumbar myelomeningocele, and coexisting neurenteric cyst. A 17-year-old ... -
Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis.
(Public Library of Science, 2008-05-14)We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ... -
Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors
(Pubmed Central, 2020)RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral ... -
Warburgia Ugandensis: A Potent in Vivo Phytomedicine Against Plasmodium Knowlesi
(Journal of Pharmacognosy and Phytochemistry, 2020)Resistance to artemisinin-based therapies by Plasmodium falciparum and the entry of P. knowlesi as the fifth human malaria parasite present an urgent need for development of safe, affordable and effective therapeutic ... -
Young Adults in Endemic Areas: An Untreated Group In Need of School-Based Preventive Chemotherapy For Schistosomiasis Control and Elimination
(PubMed Central, 2018)Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students ...
