Browsing RP-Department of Pathology by Title
Now showing items 18-34 of 34
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Mammary analogue secretory carcinoma of the salivary gland of a recently described tumour: A case report
(Kenyatta University School of Medicine, 2015)Mammary Analogue Secretory Carcinoma (MASC) is a recently described tumour of the salivary gland, characterized by the t (12; 15) (p13; q25) translocation. We report a case from a 40 year old female who presented with ... -
Management of Type 2 Diabetes Mellitus by Diabetic Clients In Nyandarua South Sub –County, Kenya
(IPRJB, 2017)Purpose: Type 2 diabetes mellitus, (T2DM) is the most common form of diabetes, characterized by disorders of insulin resistance, insulin secretion, obesity, lipid abnormalities, hypertension, and cardiovascular diseases. ... -
Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China
(National Institute of Infectious Diseases, 2016) -
Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.
(Microbes and Infection, 2009)Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, ... -
A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.
(Infection and Immunity, 2010-01)Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates ... -
Prevalence and Correlates of Alcohol Use among Underage High-School Students in Murang’a and Kajiado Counties, Kenya
(Researchjournali’s Journal of Public Health, 2015-07)Background: Alcohol use during adolescence is an important risk factor for a host of physical and social problems affecting the young people globally. There is limited data on the prevalence of alcohol use among the ... -
Reduced interferon (IFN) –α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anaemia and longitudinal all-cause mortality
(PubMed, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria
(Wiley Periodicals, Inc., 2012)Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater ... -
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
(Elsevier, 2019)The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed ... -
Socio-Demographic, Social economic and Socio-Cultural Factors that Influences Uptake of Cervical Cancer Screening Services in Low Resource Settings
(IPRJB, 2017)Background: Cervical cancer is the fourth commonest cancer in women and the seventh overall, with estimated 528,000 new cases every year. Around 85% of the global burden occurs in the low resource settings where it ... -
Suppression of RANTES in children with Plasmodium falciparum malaria.
(Haematologica, 2006-10)Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated ... -
Tethered Cord Syndrome Secondary to the Unusual Constellation of a Split Cord Malformation, Lumbar Myelomeningocele, and Coexisting Neurenteric Cyst
(Hindawi Publishing Corporation, 2012)We describe a seminal case report of a child with a tethered cord syndrome secondary to the unusual constellation of a split cord malformation, lumbar myelomeningocele, and coexisting neurenteric cyst. A 17-year-old ... -
Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis.
(Public Library of Science, 2008-05-14)We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse flies were confirmed to have mature trypanosome infections by ... -
Virus-Induced Cytoplasmic Aggregates and Inclusions are Critical Cellular Regulatory and Antiviral Factors
(Pubmed Central, 2020)RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral ... -
Warburgia Ugandensis: A Potent in Vivo Phytomedicine Against Plasmodium Knowlesi
(Journal of Pharmacognosy and Phytochemistry, 2020)Resistance to artemisinin-based therapies by Plasmodium falciparum and the entry of P. knowlesi as the fifth human malaria parasite present an urgent need for development of safe, affordable and effective therapeutic ... -
Young Adults in Endemic Areas: An Untreated Group In Need of School-Based Preventive Chemotherapy For Schistosomiasis Control and Elimination
(PubMed Central, 2018)Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students ...
