Browsing RP-Department of Pathology by Title
Now showing items 8-27 of 34
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Effect of Four Rounds of Annual School-Wide Mass Praziquantel Treatment for Schistosoma Mansoni Control on Schistosome Specific Immune Responses.
(Wiley Online Library, 2018)This study evaluated potential changes in antischistosome immune responses in children from schools that received 4 rounds of annual mass drug administration (MDA) of praziquantel (PZQ). In a repeated cross-sectional study ... -
Effects of Female Genital Schistosomiasis in Reproductive Tract of Women Attending Kwale Hospital in Kwale County, Kenya
(International Journal of TROPICAL DISEASE & Health, 2017-06-17)Background: Female genital Schistosomiasis (FGS) caused by Schistosoma haematobium is a significant public health problem among women living in endemic areas. An estimated 45 million women in sub-Saharan Africa are ... -
Expression of p53 and HER2/Neu in Kenyan Women with Primary Ovarian Carcinoma
(Lippincott, Williams & Wilkins, 2016)Ovarian carcinomas are a leading cause of cancer mortality among women. Two of the more commonly described markers of prognostic significance in primary ovarian carcinomas are p53 and HER2/neu. Overexpression of both markers ... -
Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.
(PubMed, 2011)Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ... -
Functional Studies of T Regulatory Lymphocytes in Human Schistosomiasis in Western Kenya
(The American Journal of Tropical Medicine and Hygiene, 2018)Immunoregulation is considered a common feature of Schistosoma mansoni infections, and elevated levels of T regulatory (Treg) lymphocytes have been reported during chronic human schistosomiasis. We now report that the ... -
Health Seeking Behavior, Practices of TB and Access to Health Care among TB Patients in Machakos County, Kenya. A Cross-Sectional Study
(IISTE, 2014)Despite efforts to implementation of the DOTS programme in Kenya since the year (1993) and achieving 100% coverage by the year 1996; new TB cases continue to emerge in communities, a significance of TB transmission. The ... -
HIV Prevalence among Secondary School Student Blood Donors in Nairobi County, Kenya
(International Journal of Science and Research (IJSR), 2018-07)The Human Immune deficiency Virus and the Acquired Immune Deficiency Syndrome situation in Kenya has affected blood collection in the country leading to a decline from 150,000 units to about 70,000 units annually, yet the ... -
Impact of sanitation improved school latrine on latrine-related practices, perceptions attitude and occurrence of diarrhoea in children in Mwea Division, Kirinyaga District, Central Kenya
(Kenyatta University School of Medicine, 2015)Background: School latrines in Mwea irrigation regions are unsanitary and unhygienic. School children who are the end point users of the latrines are exposed to the unhygienic conditions of the latrines and are likely ... -
Incidence of perineural invasion in prostate adenocarcinoma: Rural Kenyan population experience
(Kenyatta University, 2014)Introduction: Prostate cancer appears to be more aggressive amongst patients of African descent, a condition which could be associated with the presence of perineural invasion and higher Gleason scores of the ... -
Mammary analogue secretory carcinoma of the salivary gland of a recently described tumour: A case report
(Kenyatta University School of Medicine, 2015)Mammary Analogue Secretory Carcinoma (MASC) is a recently described tumour of the salivary gland, characterized by the t (12; 15) (p13; q25) translocation. We report a case from a 40 year old female who presented with ... -
Management of Type 2 Diabetes Mellitus by Diabetic Clients In Nyandarua South Sub –County, Kenya
(IPRJB, 2017)Purpose: Type 2 diabetes mellitus, (T2DM) is the most common form of diabetes, characterized by disorders of insulin resistance, insulin secretion, obesity, lipid abnormalities, hypertension, and cardiovascular diseases. ... -
Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China
(National Institute of Infectious Diseases, 2016) -
Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.
(Microbes and Infection, 2009)Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, ... -
A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.
(Infection and Immunity, 2010-01)Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates ... -
Prevalence and Correlates of Alcohol Use among Underage High-School Students in Murang’a and Kajiado Counties, Kenya
(Researchjournali’s Journal of Public Health, 2015-07)Background: Alcohol use during adolescence is an important risk factor for a host of physical and social problems affecting the young people globally. There is limited data on the prevalence of alcohol use among the ... -
Reduced interferon (IFN) –α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anaemia and longitudinal all-cause mortality
(PubMed, 2012-08)Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ... -
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria
(Wiley Periodicals, Inc., 2012)Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater ... -
Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
(Elsevier, 2019)The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed ...
