• English
    • français
  • English 
    • English
    • français
  • Login
View Item 
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Pure and Applied Sciences
  • RP-Department of Mathematics
  • View Item
  •   Repository Home
  • Research Papers (RP)
  • RP-School of Pure and Applied Sciences
  • RP-Department of Mathematics
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The Implications of HIV treatment on the HIV-malaria coinfection dynamics: a modeling perspective

Thumbnail
View/Open
Full article (1.870Mb)
Date
2015
Author
Nyabadza, F.
Bekele, B. T.
Rúa, M. A.
Malonza, D. M.
Chiduku, N.
Kgosimore, M.
Metadata
Show full item record
Abstract
Most hosts harbor multiple pathogens at the same time in disease epidemiology. Multiple pathogens have the potential for interaction resulting in negative impacts on host fitness or alterations in pathogen transmission dynamics. In this paper we develop a mathematical model describing the dynamics of HIV-malaria coinfection. Additionally, we extended our model to examine the role treatment (of malaria and HIV) plays in altering populations’ dynamics. Our model consists of 13 interlinked equations which allow us to explore multiple aspects of HIV-malaria transmission and treatment. We perform qualitative analysis of the model that includes positivity and boundedness of solutions. Furthermore, we evaluate the reproductive numbers corresponding to the submodels and investigate the long term behavior of the submodels. We also consider the qualitative dynamics of the full model. Sensitivity analysis is done to determine the impact of some chosen parameters on the dynamics of malaria. Finally, numerical simulations illustrate the potential impact of the treatment scenarios and confirm our analytical results
URI
http://ir-library.ku.ac.ke/handle/123456789/14150
Collections
  • RP-Department of Mathematics [81]

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback

 

 

Browse

All of RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Designed by Library ICT Team copyright © 2017 
Contact Us | Send Feedback