Antileishmanial activity of Aloe Secundiflora plant extracts against Leishmania Major (2013).
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Human leishmaniases are a spectrum of diseases caused by protozoan parasites of the genus Leishmania. In this study antileishmanial activity of the methanolic and water leaf extracts from Aloe secundiflora plant were analysed by determining the minimum inhibition concentration (MIC), nitric oxide (NO) production stimulation, infection rates (IR) and multiplication index (MI). Cytotoxicity of these plant extracts was also assessed. The MIC levels of water and methanolic plant extracts, amphotericin B and pentostam were 2000 μg/ml, 1000 μg/ml, 125μg/ml and 250 μg/ml respectively against Leishamnia major promastigotes. This study revealed that water and methanolic plant extracts significantly inhibited the growth of Leishmania parasites (P ≤ 0.05) as compared to amphotericin B with respect to the parasite infection rates and MIC levels. The IC50 for the water and methanolic plant extracts was 279.488 μg/ml and 42.824 μg/ml respectively. The elevated inhibitory activity observed in this study against Leishmania major parasites provides evidence and basis for their potential use as therapeutic agents against leishmaniasis.