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Efficacy of Trypan: a Diminazene Based Drug as Antileishmanial Agent

Gicheru, M. M.; Macharia, J. C.; Bourdichon, A. J. (PubMed, 2004)

Trypan, a diamidine based drug, was tested as an antileishmanial agent. Duplicate cultures of both Leishmania major and Leishmania donovani promastigotes in M199 medium and Trypan at various concentrations were tested. The ...

In Vitro and in Vivo Antileishmanial Efficacy of a Combination Therapy of Diminazene and Artesunate against Leishmania Donovani in BALB/c Mice.

Gicheru, M. M.; Mutiso, J. M.; Macharia, J. C.; Barasa, M.; Taracha, E.; Bourdichon, A. J. (PubMed, 2011)

The in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be ...