RP-Department of Biochemistry and Biotechnology
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Recent Submissions
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Town Scale Response of Water Viral Communities to Town Source Surface Water Contamination with Hydrochemical Parameters.
(EDP Sciences, 2023)This study aims to explore the relationship between human enteric viruses found in town-scale surface water sources and certain chemical contaminants present in the water. From October 2010 to April 2012, water samples ... -
Essential Plant Nutrients Impair Post-Germination Development of Striga in Sorghum
(Plants People Planet., 2023)Societal Impact Statement Infestation by the parasitic weed Striga is a major cause of cereal crop production losses on smallholder farms in Africa. Essential plant nutrients play an important indirect role in parasite ... -
Transgenic Expression of Arabidopsis ELONGATION FACTOR-TU RECEPTOR (AtEFR) Gene in Banana Enhances Resistance Against Xanthomonas campestris pv. musacearum
(plos one, 2023)Banana Xanthomonas wilt (BXW) caused by Xanthomonas campestris pv. musacearum (Xcm) is a severe bacterial disease affecting banana production in East and Central Africa, where banana is cultivated as a staple crop. ... -
In-Vitro Activity of Medicinal Plant Crude Extract and In-Vivo Toxicity Testing of Dichloromethane Root Extract of Citrus Limon in Laboratory Rabbits
(2022)Aims: To identify viable phytomedicines traditionally employed for the treatment of malaria in Kenya that could be developed into antimalarial agents. Study Design: Quantitative analysis of antiplasmodial activities and ... -
CLSI Guided Reference Interval Limits for Cancer Biomarkers for Adults and Geriatrics
(Ital Publication, 2022)Reference interval limits for cancer biomarkers in geriatrics are rare because priority is given to the development of reference interval limits for those in the age range of 18–60 years, which are normally used for clinical ... -
Efficacy of Artemisinin–Lumefantrine for Treatment of Uncomplicated Malaria after More Than a Decade of Its Use in Kenya
(Cambridge University Press, 2020)Background. The resistance of Plasmodium falciparum to antimalarial drugs remains a major impairment in the treatment and eradication of malaria globally. Following the introduction of artemisinin-based combination therapy ... -
Reference Ranges for Triage Room, Biochemical, Hematological and Tumour Marker Parameters for Taita-Taveta County, Kenya
(Kenyatta University, 2023)Medical diagnosis is based on information from findings such as the medical history of the client, physical examination, self-report and interviews with the patient’s relative or both clinical reports from laboratory tests ... -
Phytochemical Profiles and Bioefficacy of Methanol Extracts of Cissampelos Pareira L., Lantana Camara L., and Ocimum Gratissimum L. Against Inflammation, Pain And Fever
(Kenyatta University, 2023)Herbal medicine is an effective therapy and safe for treating and managing various illnesses. In Kenya, the Embu and Mbeere communities that reside in Embu County use, Cissampelos pareira (Menispermaceae), Lantana camara ... -
Phytochemical Composition, Anti-Rheumatoid Arthritis Potential and Toxicity Profiles of Methanol Extracts of Zanthoxylum Usambarense Engl. And Rhamnus Prinoides L’hér
(Kenyatta University, 2023)Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune ailment marked by synovial joint edema, stiffness and pain resulting in severe disability and sometimes premature fatalities. A combination of glucocorticoids, ... -
Nutritional Analysis, In Vitro Antioxidant Activity and Hepatoprotective Potential of Solanum Villosum Linn. and Solanum Scabrum Mill. Methanol Leaves Extracts
(Kenyatta University, 2023)Drug induced liver injury (DILI) is caused by prescribed drugs, herbs and various xenobiotics resulting in liver malfunctions. It remains a principal challenge associated with prescribed drugs and a leading basis for ... -
Cognitive Enhancing Effects and Antioxidant Activities of Crude Methanol Extracts of Prunus Africana in Scopolamine-Induced Alzheimer’s Disease Mice
(Kenyatta University, 2023)Alzheimer’s disease (AD) is a type of dementia marked by gradual progressive neurodegeneration caused by excessive neurofibrillary tangles and amyloid beta (Aβ) build-up in hippocampus and other parts of the brain. ... -
In Vitro Antiproliferative Effects and Phytochemical Characterization of Carissa edulis ((Forssk) Vahl) and Pappea capensis (Eckyl and Zeyh) Extracts
(SAGE, 2023)Cancer mortality is a global concern. The current therapeutic approaches despite showing efficacy are characterized by several limitations. Search for alternatives has led to the use of herbal plants including C. edulis ... -
Efficacy of Diversely Isolated Lytic Phages against Multi-Drug Resistant Enterobacter Cloacae Isolates in Kenya
(ajlm, 2022-08)Background: Enterobacter cloacae causes nosocomial infections in 15% of patients in low- and middle-income countries with emergence of carbapenem resistance. The utilisation of bacteriophages for therapeutic purposes is ... -
Reduction of Mobile Heavy Metals During Composting of Water Hyacinth Weed
(Al-Kindi Center, 2020)Water hyacinth (Eichhornia crassipes [Mart.] Solms) invasion in Lake Victoria has become a matter of concern over the last two decades. Composting of harvested water hyacinth biomass can help protect the precious lake from ... -
Revitalization of Bacterial Endophytes and Rhizobacteria for Nutrients Bioavailability in Degraded Soils to Promote Crop Production
(aims, 2021)The diverse community of endophyte and rhizobacteria is a critical resource in enhancing plant growth and resistance against abiotic and biotic stress. These microbes include various bacterial communities dominated by ...
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Town Scale Response of Water Viral Communities to Town Source Surface Water Contamination with Hydrochemical Parameters.
(EDP Sciences, 2023)This study aims to explore the relationship between human enteric viruses found in town-scale surface water sources and certain chemical contaminants present in the water. From October 2010 to April 2012, water samples ... -
Essential Plant Nutrients Impair Post-Germination Development of Striga in Sorghum
(Plants People Planet., 2023)Societal Impact Statement Infestation by the parasitic weed Striga is a major cause of cereal crop production losses on smallholder farms in Africa. Essential plant nutrients play an important indirect role in parasite ... -
Transgenic Expression of Arabidopsis ELONGATION FACTOR-TU RECEPTOR (AtEFR) Gene in Banana Enhances Resistance Against Xanthomonas campestris pv. musacearum
(plos one, 2023)Banana Xanthomonas wilt (BXW) caused by Xanthomonas campestris pv. musacearum (Xcm) is a severe bacterial disease affecting banana production in East and Central Africa, where banana is cultivated as a staple crop. ... -
In-Vitro Activity of Medicinal Plant Crude Extract and In-Vivo Toxicity Testing of Dichloromethane Root Extract of Citrus Limon in Laboratory Rabbits
(2022)Aims: To identify viable phytomedicines traditionally employed for the treatment of malaria in Kenya that could be developed into antimalarial agents. Study Design: Quantitative analysis of antiplasmodial activities and ... -
CLSI Guided Reference Interval Limits for Cancer Biomarkers for Adults and Geriatrics
(Ital Publication, 2022)Reference interval limits for cancer biomarkers in geriatrics are rare because priority is given to the development of reference interval limits for those in the age range of 18–60 years, which are normally used for clinical ... -
Efficacy of Artemisinin–Lumefantrine for Treatment of Uncomplicated Malaria after More Than a Decade of Its Use in Kenya
(Cambridge University Press, 2020)Background. The resistance of Plasmodium falciparum to antimalarial drugs remains a major impairment in the treatment and eradication of malaria globally. Following the introduction of artemisinin-based combination therapy ... -
Reference Ranges for Triage Room, Biochemical, Hematological and Tumour Marker Parameters for Taita-Taveta County, Kenya
(Kenyatta University, 2023)Medical diagnosis is based on information from findings such as the medical history of the client, physical examination, self-report and interviews with the patient’s relative or both clinical reports from laboratory tests ... -
Phytochemical Profiles and Bioefficacy of Methanol Extracts of Cissampelos Pareira L., Lantana Camara L., and Ocimum Gratissimum L. Against Inflammation, Pain And Fever
(Kenyatta University, 2023)Herbal medicine is an effective therapy and safe for treating and managing various illnesses. In Kenya, the Embu and Mbeere communities that reside in Embu County use, Cissampelos pareira (Menispermaceae), Lantana camara ... -
Phytochemical Composition, Anti-Rheumatoid Arthritis Potential and Toxicity Profiles of Methanol Extracts of Zanthoxylum Usambarense Engl. And Rhamnus Prinoides L’hér
(Kenyatta University, 2023)Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune ailment marked by synovial joint edema, stiffness and pain resulting in severe disability and sometimes premature fatalities. A combination of glucocorticoids, ... -
Cognitive Enhancing Effects and Antioxidant Activities of Crude Methanol Extracts of Prunus Africana in Scopolamine-Induced Alzheimer’s Disease Mice
(Kenyatta University, 2023)Alzheimer’s disease (AD) is a type of dementia marked by gradual progressive neurodegeneration caused by excessive neurofibrillary tangles and amyloid beta (Aβ) build-up in hippocampus and other parts of the brain. ... -
Nutritional Analysis, In Vitro Antioxidant Activity and Hepatoprotective Potential of Solanum Villosum Linn. and Solanum Scabrum Mill. Methanol Leaves Extracts
(Kenyatta University, 2023)Drug induced liver injury (DILI) is caused by prescribed drugs, herbs and various xenobiotics resulting in liver malfunctions. It remains a principal challenge associated with prescribed drugs and a leading basis for ... -
In Vitro Antiproliferative Effects and Phytochemical Characterization of Carissa edulis ((Forssk) Vahl) and Pappea capensis (Eckyl and Zeyh) Extracts
(SAGE, 2023)Cancer mortality is a global concern. The current therapeutic approaches despite showing efficacy are characterized by several limitations. Search for alternatives has led to the use of herbal plants including C. edulis ... -
Reduction of Mobile Heavy Metals During Composting of Water Hyacinth Weed
(Al-Kindi Center, 2020)Water hyacinth (Eichhornia crassipes [Mart.] Solms) invasion in Lake Victoria has become a matter of concern over the last two decades. Composting of harvested water hyacinth biomass can help protect the precious lake from ... -
Revitalization of Bacterial Endophytes and Rhizobacteria for Nutrients Bioavailability in Degraded Soils to Promote Crop Production
(aims, 2021)The diverse community of endophyte and rhizobacteria is a critical resource in enhancing plant growth and resistance against abiotic and biotic stress. These microbes include various bacterial communities dominated by ... -
Magnitude and Geographical Distribution of Nontuberculous Mycobacteria among People Presumed to Have Pulmonary Tuberculosis in Kenya
(ajhs, 2021)Globally, awareness of nontuberculous mycobacteria as causative agents of pulmonary disease is on the rise. In Kenya however, there is very limited information on the burden of nontuberculous mycobacteria, as diagnosis of ... -
Efficacy of Diversely Isolated Lytic Phages against Multi-Drug Resistant Enterobacter Cloacae Isolates in Kenya
(ajlm, 2022-08)Background: Enterobacter cloacae causes nosocomial infections in 15% of patients in low- and middle-income countries with emergence of carbapenem resistance. The utilisation of bacteriophages for therapeutic purposes is ... -
Subacute Toxicity Effects of the Aqueous Shoot Extract of Yushania Alpina (K. Schum.) W.C.Lin in Sprague Dawley Rats: An Appraisal of Its Safety in Ethnomedicinal Usage
(Hindawi, 2022)Plant-based medicines have effectively managed several ailments in humans and animals since prehistoric times. However, the pharmacologic efficacy and safety of many plants currently used in traditional medicine have not ... -
Antimicrobial Activity, Cytotoxicity, and Qualitative Phytochemical Composition of Aqueous and Methanolic Leaf Extracts of Physalis Peruviana L. (Solanaceae)
(The Journal of Phytopharmacology, 2023)Background: The high morbidity and mortality associated with microbial infections and the ineffectiveness of conventional antibiotics due to inappropriate use and resistance warrant alternative stratagems. Aim: We ... -
Occurrence of Enteric Viruses in Surface Water and the Relationship with Changes in Season and Physical Water Quality Dynamics
(2020)Environmental water quality issues have dominated global discourse and studies over the past five decades. Significant parameters of environmental water quality include changes in biological and physical parameters. Some ... -
Banana Production Trends, Cultivar Diversity, and Tissue Culture Technologies Uptake in Kenya
(International Journal of Agronomy, 2021-02)Banana (Musa acuminate L) is the world’s most widely known and distributed fruit and is a great contributor to food security in the developing world. However, many limiting factors affect banana farming, which cut across ...
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