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Polymorphic Variability in the Interleukin (IL)-1Beta Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL-1Beta Production

Otieno, Micheal Frederick; Ouma, C.; Davenport, G. C.; Awandare, G. A.; Keller, C. C.; Were, T.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R. E.; Perkins, D. J. (PubMed, 2008-10)

Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe ...

Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.

Were, T.; Davenport, G. C.; Yamo, EO; Hittner, James B.; Awandare, GA; Otieno, Micheal Frederick; Ouma, C; Orago, A. S.; Vulule, JM; Ong'echa, J. M.; Perkins, D. J. (Microbes and Infection, 2009)

Regulated upon activation, normal T-cell expressed, and secreted (RANTES, CCL-5) is an important immunoregulatory mediator that is suppressed in children with malarial anemia (MA). Although proinflammatory (e.g. TNF-α, ...

Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production.

Ouma, C.; Davenport, G. C.; Were, T.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R. E.; Perkins, D. J. (Human Genetics, 2008-11)

Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria

Davenport, G. C.; Hittner, James B.; Were, T.; Ong'echa, J. M.; Perkins, D. J. (Wiley Periodicals, Inc., 2012)

Anemia is the primary hematological manifestation of both Plasmodium falciparum malaria and HIV-1 in pediatric populations in sub-Saharan Africa. We have previously shown that HIV-1 positive and exposed children have greater ...

Functional promoter haplotypes of interleukin-18 condition susceptibility to severe malarial anemia and childhood mortality.

Were, T.; Gichuki, C.W.; Ong'echa, J. M.; Ouma, Collins; Anyona, S.B.; Kempaiah, P.; Raballah, E.; Davenport, G. C.; Konah, S.N.; Vulule, J.M.; Hittner, James B.; Perkins, D. J. (PubMed, 2011)

Severe malarial anemia (SMA) is a leading cause of morbidity and mortality in children residing in regions where plasmodium falciparum transmission is holoendemic. Although largely unexplored in children with SMA, ...

Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

Ouma, C.; Keller, C.C.; Opondo, D.A.; Were, T.; Otieno, Richard O.; Otieno, Micheal Frederick; Orago, A. S.; Ong'echa, J. M.; Vulule, JM; Ferrell, RE; Perkins, D. J. (American Journal of Tropical Medicine and Hygiene, 2006-04)

Suppression of RANTES in children with Plasmodium falciparum malaria.

Were, T.; Hittner, James B.; Ouma, C.; Otieno, Richard O.; Orago, A. S.; Ong'echa, J. M.; Vulule, J. M.; Keller, C. C.; Perkins, D. J. (Haematologica, 2006-10)

Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated ...

A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.

Ouma, C.; Keller, C.C.; Davenport, G. C.; Were, T.; Konah, S.; Otieno, Micheal Frederick; Hittner, James B.; Vulule, J. M.; Martinson, J.; Ong'echa, J. M.; Ferrell, R.E.; Perkins, D. J. (Infection and Immunity, 2010-01)

Plasmodium falciparum malaria is a leading global cause of infectious disease burden. In areas in which P. falciparum transmission is holoendemic, such as western Kenya, severe malarial anemia (SMA) results in high rates ...

Reduced interferon (IFN) –α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anaemia and longitudinal all-cause mortality

Were, T.; Kempaiah, P.; Anyona, S. B.; Raballah, E.; Davenport, G. C.; Hittner, James B.; Ong'echa, J. M.; Perkins, D. J. (PubMed, 2012-08)

Severe malarial anemia (SMA) is a leading cause of pediatric morbidity and mortality in holoendemic Plasmodium falciparum transmission areas. Although dysregulation in cytokine production is an important etiology of SMA, ...