|dc.identifier.citation||East and Central Africa Medical Journal 2015; 2(1): 7-9||en_US
|dc.description||This article was scanned from a hard copy of the East and Central Africa medical journal Vol.2 no1 2015||en_US
|dc.description.abstract||Introduction: Prostate cancer appears
to be more aggressive amongst patients
of African descent, a condition which
could be associated with the presence of
perineural invasion and higher Gleason
scores of the cancer.
Objective: This study evaluated the
incidence of perineural invasion in
previously diagnosed prostate cancer cases
in a rural hospital which receive numerous
cases of prostate cancer annually.
Setting: This was a retrospective cross
sectional study conducted at a busy
mission referral hospital in rural Kenya.
A total of 151 cases were included in
the study. Patients' biodata was retrieved
from the laboratory information system.
Hematoxylin and eosin stained slides of
previously diagnosed cases of prostate
cancer over a period of one year (January
2012 to December 2012) were retrieved.
These slides were microscopically
examined for perineural invasion and the
tumour grade determined using Gleason
Results: Specimens from 151 patients
were examined for perineural invasion.
The patients' ages ranged from 46 to 93,
mean age 73.77 (SD 9.474).Tumours
in high grade category were 75.5% of
the total number of cases while the rest
(24.5%) were intennediatellow grade
tumours. Out of these, 55.6% of the
biopsies had perineural invasion. There
was no significant relationship between
the patients' age and the grade of tumour.
Data on comparison of the cancers with
perineural invasion and those without
perineural invasion for grade demonstrated
significant association between the tumour
grade and the presence of perineural
|dc.subject||Rural Kenyan African population||en_US
|dc.title||Incidence of perineural invasion in prostate adenocarcinoma: Rural Kenyan population experience||en_US