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dc.contributor.authorNjeru, Annastasia Wangari
dc.date.accessioned2014-12-02T12:04:22Z
dc.date.available2014-12-02T12:04:22Z
dc.date.issued2014
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/11815
dc.description.abstractMalaria, a parasitic infection transmitted by mosquitoes, is one of the most devastating infectious diseases and contributes very significantly to maternal and foetal mortality. Microscopic analysis has been the standard diagnostic technique for identifying malaria infections for more than a century but is unable to detect all infections as parasites can be sequestered in the placenta. Good quality microscopy is also lacking in many resourcelimited settings, as it requires well-trained, competent personnel, infrastructure as well as effective quality control and assurance. It is also labour-intensive and time-consuming, sensitivity decreases as the density of malarial parasites in the blood decreases. The problems associated with implementing and sustaining a high level of skilled microscopy appropriate for clinical diagnosis, particularly in the field setting, have prompted the development of a variety of technologically simple malaria rapid diagnostic tests. Rapid immunochromatographic test may provide a solution as emerging evidence suggests that they are capable of detecting Plasmodiumfalciparum which sequesters in the intervillous space of the placenta better than microscopy. The proposed study aims at evaluating the performance of the rapid immunochromatographic strip test and microscopy in determination of malaria prevalence during pregnancy using polymerase chain reaction as a confirmatory test. The study targets the primary health care setting using Kericho District Hospital, Kipsitet and Fort Ternan Health Centres which represent resourcelimited setting, reliant on microscopy as malaria diagnostic test. They lack well-trained, competent personnel, infrastructure as well as effective quality control and quality assurance to make accurate diagnosis. Participants will be drawn from a population of pregnant women aged 18 years and above, who have malaria symptoms and are not on antimalarial drugs attending antenatal care visits. Using microscopy as the gold standard, Polymerase Chain Reaction as a confirmatory test, the sensitivity, specificity, negative predictive value and positive predictive value of the IC test will be determined. The prevalence of malaria among expectant mothers will also be determined using microscopy and rapid ICTs. Data analysis will be done using SPSS version 17. McNemar's Chi square statistic will be used to test the level of agreement between the two tests. The findings of this study will be crucial in determining the suitability and reliability of rapid immunochromatographic test that will allow community health care workers to make rapid and accurate diagnosis of malaria in expectant mothers and make immediate therapeutic decisionsen_US
dc.description.sponsorshipKenyatta Universityen_US
dc.language.isoenen_US
dc.publisherKenyatta Universityen_US
dc.titlePerformance of rapid immunochromatographic test and microscopy in determination of malaria prevalence among expectant women in Kericho county hospitals, kenyaen_US
dc.typeThesisen_US


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