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dc.contributor.authorMburu, D. N.
dc.contributor.authorMbugua, S. W.
dc.contributor.authorSkoglund, L. A.
dc.contributor.authorLokken, P.
dc.date.accessioned2014-06-25T13:04:58Z
dc.date.available2014-06-25T13:04:58Z
dc.date.issued1988-06
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics Volume 11, Issue 2, pages 163–171, June 1988en_US
dc.identifier.issn0140-7783
dc.identifier.other1365-2885
dc.identifier.urihttp://ir-library.ku.ac.ke/handle/123456789/10134
dc.descriptionDOI: 10.1111/j.1365-2885.1988.tb00137.xen_US
dc.description.abstractIn placebo-controlled cross-over trials in dogs, two ‘identical’ operations were performed on the forelimbs of each animal with an interval of 28 days, to evaluate how daily doses of 1.5 g paracetamol, 1.5 g acetylsalicylic acid (ASA) and 0.5 g ASA might modulate an acute post-operative inflammatory reaction. On the third post-operative day the reductions in swelling compared with placebo averaged 33% with 1.5 g paracetamol (P = 0.02), 24% with 1.5 g ASA (P = 0.03) and 15% with 0.5 g ASA (P= 0.18); while the reductions in pain estimates averaged 47% with 1.5 g paracetamol (P= 0.01), 32% with 1.5 g ASA (P= 0.07) and 28% with 0.5 g ASA {P= 0.21). There were no clinical signs of adverse drug effects, such as vomiting, haematochezia, cyanosis or depression. The results disagree with the traditional view that paracetamol has little or no anti-inflammatory effect, and demonstrate that paracetamol may reduce an acute inflammatory reaction, at least as efficiently as ASA. The potential proinflammatory effect of ASA in low doses is discussed. It is concluded that paracetamol appears to be a valuable drug against post-operative or post-traumatic sequelae in the veterinary as well as in the human clinic.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.titleEffects of paracetamol and acetylsalicylic acid on the post-operative course after experimental orthopaedic surgery in dogsen_US
dc.typeArticleen_US


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