The preparation of 5-hydroxymethyl-2-furaldehyde (HMF) from d-fructose in the presence of DMSO
Musau, R. M
Munavu, R. M.
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5-Hydroxymethyl-2-furaldehyde (HMF, 1) was produced in 92% yield when d-fructose was dehydrated using dimethylsulphoxide (DMSO) at 150°C for 2 h. The optimum conversion occurred at a d-Fructose: DMSO molar ratioof 8.0. In addition to HMF, small quantities (⪷ 1%) of oxobis (5-methyl-2-furaldehyde), 4, were also obtained from the reaction. The amount of 4 was substantially increased (⪷ 30%) when the reaction was carried out in toluene as the solvent with borontrifluoride etherate as the catalyst