Antiparasitic compounds from East African plants: Isolation and biological activity of anonaine, matricarianol, canthin-6-one and caryophyllene oxide
Borgonovi, G. E.
Ogoche, J. I. J.
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Five natural compounds possessing antiparasitic activity were isolated from East African plants and tested, together with some semisynthetic derivatives, against micro-organisms and arthropods of agricultural interest. Anonaine (1), from Annona squamosa, canthin-6-one(8) and 5-methoxycanthin-6-one (9), from Fagaropsis angolensis, showed fungicidal activity. E,Z-matricarianol (4), from Hoehnelia vernonioides was fungicidal, Insecticidal and acarlcldal. Caryophyllene oxide (12), isolated from Uvaria sp., turned out to be insecticidal and antifeedant. Canthin-6-one (8) and its dihydroderivative 11 were the most effective antimicrobial compounds tested. The possibility ofusing some of the isolated compounds as leads for new synthetic chemicals is discussed.