Studies on Interaction of Schistosoma Mansoni and Leishmania Major in Experimentally Infected BALB/c Mice.
Gicheru, M. M.
Yole, D. S.
Shamala, K. T.
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Schistosoma mansoni and Leishmania major are important tropical human parasites. It is crucial to know the effect of the two infecting man concurrently. Two groups of BALB/c mice were infected with each of the parasites separately; another group was co-infected with both parasites and there was a naïve control. Draining lymph node and spleen cells from mice infected with either of the parasites showed high proliferative responses to their specific parasite antigen. However, cross-reactivity occurred between S. mansoni and L. major. Spleen and Lymph node cells from co-infected group demonstrated high and sustained proliferative responses to schistosome soluble worm antigen preparation and killed Leishmania major antigen, respectively. There was high and sustained IgG levels for both the single and co infected groups. At 10 weeks post-infection, co-infected mice had significantly larger nodules than mice with L. major infection alone. However, co-infected animals had less severe liver pathology and less enlarged mesenteric lymph nodes than those infected with S. mansoni only. This work shows that co-infection results in two different outcomes: protection against S. mansoni and exacerbated pathogy in L. major. We suggest that cellular responses possibly protect against S. mansoni, while high IgG levels lead to exacerbated L. major response.