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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants.

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dc.contributor.author Hassanali, Ahmed
dc.contributor.author Malebo, H. M.
dc.contributor.author Tanja, W.
dc.contributor.author Swaleh, S A M
dc.contributor.author Omolo, M O
dc.contributor.author Hamburger, M
dc.contributor.author Brun, R
dc.contributor.author Ndiege, I. O.
dc.date.accessioned 2013-05-17T12:27:50Z
dc.date.available 2013-05-17T12:27:50Z
dc.date.issued 2009-10-04
dc.identifier.citation Tanzania Journal of Health Research, Vol. 11, No. 4, October 2009 en_US
dc.identifier.uri http://ir-library.ku.ac.ke/handle/123456789/6810
dc.description.abstract The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae), Drypetes natalensis (Euphorbiaceae), Acridocarpus chloropterus (Malpighiaceae), Maytenus senegalensis (Celastraceae) and Neurautanenia mitis (Papilonaceae), were evaluated in vitro against Plasmodium falciparum K1, Trypanosoma brucei rhodesiense STIB 900 and axenic Leishmania donovani MHOM-ET-67/82. Out of the 25 extracts tested, 17 showed good antiplasmodial activity (IC50 0.04-5.0 μg/ml), 7 exhibited moderate anti-trypanosomal activity (IC50 2.3- 2.8 μg/ml), while 5 displayed mild anti-leishmanial activity (IC50 8.8-9.79 μg/ml). A. kummeriae, A. annua, P. microcarpa, D. natalensis, M. senegalensis and N. mitis extracts had good antiplasmodial activity (IC50 0.04-2.1 μg/ml) and selectivity indices (29.2-2,250 μg/ml). The high antiplasmodial, moderate anti-trypanosomal and mild anti-leishmanial activity make these plants good candidates for bioassay-guided isolation of anti-protozoal compounds which could serve as new lead structures for drug development. en_US
dc.language.iso en en_US
dc.publisher Tanzania Journal of Health Research en_US
dc.subject Malaria en_US
dc.subject trypanosomiasis en_US
dc.subject leishmaniasis en_US
dc.subject medicinal plants en_US
dc.subject Tanzania en_US
dc.title Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants. en_US
dc.type Article en_US


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