Kenyatta

RP-Department of Health Management & Informatics

Kenyatta University Institutional Repository

This collection contains research and other publications generated and held within Kenyatta University. Full text access is provided under Creative Commons License

RP-Department of Health Management & Informatics

 

Recent Submissions

  • Ochieng, G.O.; Keogh, Sarah C.; Fry, Kenzo; Mbugua, Edwin; Ayallo, Mark; Quinn, Heidi; Ngo, Thoai D. (BioMed Central, 2014)
    Background: Vocal local (VL) is a non-pharmacological pain management technique for gynecological procedures. In Africa, it is usually used in combination with pharmacological analgesics. However, analgesics are associated ...
  • Otieno, F. G.; Shi, L.; Zhang, X.; Golhar, R.; He, M.; Hou, C.; Kim, C.; Keating, B.; Lyon, G.J.; Wang, K.; Hakonarson, H. (BioMed Central, 2013)
    Background: Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for ...
  • Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • Otieno, F. G.; Matsunami, Nori; Hensel, Charles H; Baird, Lisa; Stevens, Jeff; Otterud, Brith; Leppert, Tami; Varvil, Tena; Hadley, Dexter; Glessner, Joseph T; Pellegrino, Renata; Kim, Cecilia; Thomas, Kelly; Wang, Fengxiang; Ho, Karen; Christensen, Gerald B; Li, Dongying; Prekeris, Rytis; Lambert, Christophe G; Hakonarson, H.; Leppert, Mark F (BioMed Central, 2014)
    Background: Genetics clearly plays a major role in the etiology of autism spectrum disorders (ASDs), but studies to date are only beginning to characterize the causal genetic variants responsible. Until recently, studies ...
  • Otieno, F. G.; Wang, Kai; Kim, Cecilia; Bradfield, Jonathan; Guo, Yunfei; Toskala, Elina; Hou, Cuiping; Thomas, Kelly; Cardinale, Christopher; Lyon, Gholson J; Golhar, Ryan; Hakonarson, Hakon (BioMed Central, 2013)
    Background: Whole-exome sequencing has identified the causes of several Mendelian diseases by analyzing multiple unrelated cases, but it is more challenging to resolve the cause of extremely rare and suspected Mendelian ...
  • Otieno, F. G.; Lanktree, M.B.; Guo, Y.; Murtaza, M.; Glessner, J.T. (Elsevier, 2011)
    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 ...
  • Otieno, G. O.; Hosoi, R. (The Health Information Management Association of Australia Limited, 2006)
    This study examines the effect of three factors: information technology (IT) skills of healthcare workers, present status of computerisation in their organisations, and workers' attitudes on the diffusion of electronic ...
  • Hakonarson, H.; Qu, H.; Bradfield, J. P.; Marchand, L.; Kim, C. E.; Glessner, J. T.; Grabs, R.; Casalunovo, T.; Taback, S. P.; Frackelton, E. C.; Eckert, A. W.; Annaiah, K.; Lawson, M. L.; Otieno, George Ochieng; Santa, E.; Shaner, J. L.; Smith, R. M.; Onyiah, C. C.; Skraban, R.; Chiavacci, R. M.; Robinson, L. J.; Stanley, C. A.; Kirsch, S. E.; Devoto, M.; Monos, D. S.; Grant, S. F. A.; Polychronakos, C. (American Diabetes Association, 2008-04)
    OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one locus at 16p13 was detected (P = 1.03 × 10−10) and confirmed in two additional cohorts. Here we describe the results of testing, in ...
  • Sleiman, P. M. A.; Annaiah, K.; Imielinski, M.; Bradfield, J. P.; Kim, C. E.; Frackelton, E. C.; Glessner, J. T.; Eckert, A. W.; Otieno, F. G.; Santa, E.; Thomas, K.; Smith, R. M.; Glaberson, W.; Garris, M.; Gunnlaugsson, S.; Chiavacci, R. M.; Allen, J.; Spergel, J.; Grundmeier, R.; Grunstein, M. M.; Magnusson, M.; Bisgaard, H.; Grant, S. F. A.; Hakonarson, H. (Elsevier, 2008-12)
  • Baldassano, R. N.; Bradfield, J. P.; Monos, D. S.; Kim, C. E.; Glessner, J. T.; Casalunovo, T.; Frackelton, E. C.; Otieno, F. G.; Kanterakis, S.; Shaner, J. L.; Smith, R. M.; Eckert, A. W.; Robinson, L. J.; Onyiah, C. C.; Abrams, D. J.; Chiavacci, R. M.; Skraban, R.; Devoto, M.; Grantemail, S. F. A.; Hakonarson, H. (WB Saunders, 2007-08)
    Background & Aims: Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn’s disease (CD) as a consequence of a genome-wide ...
  • Otieno, George Ochieng; Grant, S. F. A.; Wang, K.; Zhang, H.; Glaberson, W.; Annaiah, K.; Kim, C. E.; Bradfield, J. P.; Glessner, J. T.; Thomas, K. A.; Garris, M.; Frackelton, E. C.; Chiavacci, R. M.; Nah, H.; Kirschner, R. E.; Hakonarson, H. (2009-12)
    Objective To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Study design We performed a genome-wide association study in a ...
  • Otieno, George Ochieng; Zhao, J.; Bradfield, J. P.; Li, M.; Wang, K.; Zhang, H.; Kim, C. E.; Annaiah, K.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Otieno, F. G.; Shaner, J. L.; Smith, R. M.; Chiavacci, R. M.; Berkowitz, R. I.; Hakonarson, H.; Grant, S. F. A. (Wiley, 2009-12)
    The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis ...
  • Otieno, George Ochieng; Grant, S. F. A.; Bradfield, J. P.; Zhang, H.; Wang, K.; Kim, C. E.; Annaiah, K.; Santa, E.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Shaner, J. L.; Smith, R. M.; Imielinski, M.; Chiavacci, R. M.; Li, M.; Berkowitz, R. I.; Hakonarson, H. (Wiley, 2009-07)
    Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3′ of the MC4R locus as a consequence of a meta-analysis of genome-wide ...
  • Otieno, George Ochieng; Behrens, E. M.; Finkel, T. H.; Bradfield, J. P.; Kim, C. E.; Linton, L.; Casalunovo, T.; Frackelton, E. C.; Santa, E.; Glessner, J. T.; Chiavacci, R. M.; Grant, S. F. A.; Hakonarson, H. (Wiley, 2008-07)
  • Keraka, M. (Food Security Problems in Borabu Division, Nyamira District, 2005-09-13)
    This paper highlights the food security problems in Borabu Division, Nyamira District. It focuses on the concept of the relationship between population growth and land use. Secondly, it examines the influence of changing ...
  • Otieno, George Ochieng; Grant, S.F.; Li, M.; Bradfield, J.P.; Kim, C.E.; Annaiah, K.; Santa, E.; Glessner, J.T.; Casalunovo, T.; Frackelton, E.C.; Shaner, J.L.; Smith, R.M.; Imielinski, M.; Eckert, A.W.; Chiavacci, R.M.; Berkowitz, R.I.; Hakonarson, H. (Public Library of Science, 2008-03)
    Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. ...
  • Otieno, George Ochieng; Kugathasan, S.; Baldassano, R.N.; Bradfield, J.P.; Sleiman, P.M.; Imielinski, M.; Guthery, S.L.; Cucchiara, S.; Kim, C.E.; Frackelton, E.C.; Annaiah, K.; Glessner, J.T.; Santa, E.; Willson, T.; Eckert, A.W.; Bonkowski, E.; Shaner, J.L.; Smith, R.M.; Peterson, N.; Abrams, D.J.; Chiavacci, R.M.; Grundmeier, R.; Mamula, P.; Tomer, G.; Piccoli, D.A.; Monos, D.S.; Annese, V.; Denson, L.A.; Grant, S.F.; Hakonarson, H. (Nature Publishing Group -, 2008-09)
    Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal ...
  • Ochieng, Otieno, George; Shaikh, T.H.; Gai, X.; Perin, J.C.; Glessner, J.T.; Casalunovo, T.; Xie, H.; Murphy, K.; O'Hara, R.; Conlin, L.K.; D'Arcy, M.; Frackelton, E.C.; Geiger, E.A.; Haldeman-Englert, C.; Imielinski, M.; Kim, C.E.; Medne, L.; Annaiah, K.; Bradfield, J.P.; Dabaghyan, E. (Cold Spring Harbor Laboratory Press, 2009-09-19)
    We present a database of copy number variations (CNVs) detected in 2026 disease-free individuals, using high-density, SNP-based oligonucleotide microarrays. This large cohort, comprised mainly of Caucasians (65.2%) and ...
  • Otieno, George Ochieng; Glessner, J.T.; Wang, K.; Cai, Guiqing; Korvatska, Olena; Kim, Cecilia. E.; Wood, Shawn (Nature Publishing Group, 2009-05-28)
    Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) ...

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