Recent Submissions

  • Vocal local versus pharmacological treatments for pain management in tubal ligation procedures in rural Kenya: a non-inferiority trial 

    Ochieng, G.O.; Keogh, Sarah C.; Fry, Kenzo; Mbugua, Edwin; Ayallo, Mark; Quinn, Heidi; Ngo, Thoai D. (BioMed Central, 2014)
    Background: Vocal local (VL) is a non-pharmacological pain management technique for gynecological procedures. In Africa, it is usually used in combination with pharmacological analgesics. However, analgesics are associated ...
  • Whole-genome sequencing in an autism multiplex family 

    Otieno, F. G.; Shi, L.; Zhang, X.; Golhar, R.; He, M.; Hou, C.; Kim, C.; Keating, B.; Lyon, G.J.; Wang, K.; Hakonarson, H. (BioMed Central, 2013)
    Background: Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for ...
  • Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement 

    Otieno, F. G.; Wang, Kai; Kim, Cecilia; Bradfield, Jonathan; Guo, Yunfei; Toskala, Elina; Hou, Cuiping; Thomas, Kelly; Cardinale, Christopher; Lyon, Gholson J; Golhar, Ryan; Hakonarson, Hakon (BioMed Central, 2013)
    Background: Whole-exome sequencing has identified the causes of several Mendelian diseases by analyzing multiple unrelated cases, but it is more challenging to resolve the cause of extremely rare and suspected Mendelian ...
  • Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. 

    Otieno, F. G.; Lanktree, M.B.; Guo, Y.; Murtaza, M.; Glessner, J.T. (Elsevier, 2011)
    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 ...
  • Erratum to: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population 

    Otieno, F. G.; Matsunami, Nori; Hensel, Charles H; Baird, Lisa; Stevens, Jeff; Otterud, Brith; Leppert, Tami; Varvil, Tena; Hadley, Dexter; Glessner, Joseph T; Pellegrino, Renata; Kim, Cecilia; Thomas, Kelly; Wang, Fengxiang; Ho, Karen; Christensen, Gerald B; Li, Dongying; Prekeris, Rytis; Lambert, Christophe G; Hakonarson, H.; Leppert, Mark F (BioMed Central, 2014)
    Background: Genetics clearly plays a major role in the etiology of autism spectrum disorders (ASDs), but studies to date are only beginning to characterize the causal genetic variants responsible. Until recently, studies ...
  • Factors Influencing Diffusion of Electronic Medical Records: A Case Study in Three Healthcare Institutions in Japan 

    Otieno, G. O.; Hosoi, R. (The Health Information Management Association of Australia Limited, 2006)
    This study examines the effect of three factors: information technology (IT) skills of healthcare workers, present status of computerisation in their organisations, and workers' attitudes on the diffusion of electronic ...
  • A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study 

    Hakonarson, H.; Qu, H.; Bradfield, J. P.; Marchand, L.; Kim, C. E.; Glessner, J. T.; Grabs, R.; Casalunovo, T.; Taback, S. P.; Frackelton, E. C.; Eckert, A. W.; Annaiah, K.; Lawson, M. L.; Otieno, George Ochieng; Santa, E.; Shaner, J. L.; Smith, R. M.; Onyiah, C. C.; Skraban, R.; Chiavacci, R. M.; Robinson, L. J.; Stanley, C. A.; Kirsch, S. E.; Devoto, M.; Monos, D. S.; Grant, S. F. A.; Polychronakos, C. (American Diabetes Association, 2008-04)
    OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one locus at 16p13 was detected (P = 1.03 × 10−10) and confirmed in two additional cohorts. Here we describe the results of testing, in ...
  • ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry 

    Sleiman, P. M. A.; Annaiah, K.; Imielinski, M.; Bradfield, J. P.; Kim, C. E.; Frackelton, E. C.; Glessner, J. T.; Eckert, A. W.; Otieno, F. G.; Santa, E.; Thomas, K.; Smith, R. M.; Glaberson, W.; Garris, M.; Gunnlaugsson, S.; Chiavacci, R. M.; Allen, J.; Spergel, J.; Grundmeier, R.; Grunstein, M. M.; Magnusson, M.; Bisgaard, H.; Grant, S. F. A.; Hakonarson, H. (Elsevier, 2008-12)
  • Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn’s Disease 

    Baldassano, R. N.; Bradfield, J. P.; Monos, D. S.; Kim, C. E.; Glessner, J. T.; Casalunovo, T.; Frackelton, E. C.; Otieno, F. G.; Kanterakis, S.; Shaner, J. L.; Smith, R. M.; Eckert, A. W.; Robinson, L. J.; Onyiah, C. C.; Abrams, D. J.; Chiavacci, R. M.; Skraban, R.; Devoto, M.; Grantemail, S. F. A.; Hakonarson, H. (WB Saunders, 2007-08)
    Background & Aims: Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn’s disease (CD) as a consequence of a genome-wide ...
  • A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24 

    Otieno, George Ochieng; Grant, S. F. A.; Wang, K.; Zhang, H.; Glaberson, W.; Annaiah, K.; Kim, C. E.; Bradfield, J. P.; Glessner, J. T.; Thomas, K. A.; Garris, M.; Frackelton, E. C.; Chiavacci, R. M.; Nah, H.; Kirschner, R. E.; Hakonarson, H. (2009-12)
    Objective To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Study design We performed a genome-wide association study in a ...
  • Investigation of the Locus Near MC4R With Childhood Obesity in Americans of European and African Ancestry 

    Otieno, George Ochieng; Grant, S. F. A.; Bradfield, J. P.; Zhang, H.; Wang, K.; Kim, C. E.; Annaiah, K.; Santa, E.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Shaner, J. L.; Smith, R. M.; Imielinski, M.; Chiavacci, R. M.; Li, M.; Berkowitz, R. I.; Hakonarson, H. (Wiley, 2009-07)
    Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3′ of the MC4R locus as a consequence of a meta-analysis of genome-wide ...
  • Association of the TRAF1–C5 locus on chromosome 9 with juvenile idiopathic arthritis 

    Otieno, George Ochieng; Behrens, E. M.; Finkel, T. H.; Bradfield, J. P.; Kim, C. E.; Linton, L.; Casalunovo, T.; Frackelton, E. C.; Santa, E.; Glessner, J. T.; Chiavacci, R. M.; Grant, S. F. A.; Hakonarson, H. (Wiley, 2008-07)
  • The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI 

    Otieno, George Ochieng; Zhao, J.; Bradfield, J. P.; Li, M.; Wang, K.; Zhang, H.; Kim, C. E.; Annaiah, K.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Otieno, F. G.; Shaner, J. L.; Smith, R. M.; Chiavacci, R. M.; Berkowitz, R. I.; Hakonarson, H.; Grant, S. F. A. (Wiley, 2009-12)
    The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis ...
  • Vocal local versus pharmacological treatments for pain management in tubal ligation procedures in rural Kenya: a non-inferiority trial 

    Ochieng, G.O.; Keogh, Sarah C.; Fry, Kenzo; Mbugua, Edwin; Ayallo, Mark; Quinn, Heidi; Ngo, Thoai D. (BioMed Central, 2014)
    Background: Vocal local (VL) is a non-pharmacological pain management technique for gynecological procedures. In Africa, it is usually used in combination with pharmacological analgesics. However, analgesics are associated ...
  • Whole-genome sequencing in an autism multiplex family 

    Otieno, F. G.; Shi, L.; Zhang, X.; Golhar, R.; He, M.; Hou, C.; Kim, C.; Keating, B.; Lyon, G.J.; Wang, K.; Hakonarson, H. (BioMed Central, 2013)
    Background: Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for ...
  • Erratum to: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population 

    Otieno, F. G.; Matsunami, Nori; Hensel, Charles H; Baird, Lisa; Stevens, Jeff; Otterud, Brith; Leppert, Tami; Varvil, Tena; Hadley, Dexter; Glessner, Joseph T; Pellegrino, Renata; Kim, Cecilia; Thomas, Kelly; Wang, Fengxiang; Ho, Karen; Christensen, Gerald B; Li, Dongying; Prekeris, Rytis; Lambert, Christophe G; Hakonarson, H.; Leppert, Mark F (BioMed Central, 2014)
    Background: Genetics clearly plays a major role in the etiology of autism spectrum disorders (ASDs), but studies to date are only beginning to characterize the causal genetic variants responsible. Until recently, studies ...
  • Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement 

    Otieno, F. G.; Wang, Kai; Kim, Cecilia; Bradfield, Jonathan; Guo, Yunfei; Toskala, Elina; Hou, Cuiping; Thomas, Kelly; Cardinale, Christopher; Lyon, Gholson J; Golhar, Ryan; Hakonarson, Hakon (BioMed Central, 2013)
    Background: Whole-exome sequencing has identified the causes of several Mendelian diseases by analyzing multiple unrelated cases, but it is more challenging to resolve the cause of extremely rare and suspected Mendelian ...
  • Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. 

    Otieno, F. G.; Lanktree, M.B.; Guo, Y.; Murtaza, M.; Glessner, J.T. (Elsevier, 2011)
    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 ...
  • Factors Influencing Diffusion of Electronic Medical Records: A Case Study in Three Healthcare Institutions in Japan 

    Otieno, G. O.; Hosoi, R. (The Health Information Management Association of Australia Limited, 2006)
    This study examines the effect of three factors: information technology (IT) skills of healthcare workers, present status of computerisation in their organisations, and workers' attitudes on the diffusion of electronic ...
  • A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study 

    Hakonarson, H.; Qu, H.; Bradfield, J. P.; Marchand, L.; Kim, C. E.; Glessner, J. T.; Grabs, R.; Casalunovo, T.; Taback, S. P.; Frackelton, E. C.; Eckert, A. W.; Annaiah, K.; Lawson, M. L.; Otieno, George Ochieng; Santa, E.; Shaner, J. L.; Smith, R. M.; Onyiah, C. C.; Skraban, R.; Chiavacci, R. M.; Robinson, L. J.; Stanley, C. A.; Kirsch, S. E.; Devoto, M.; Monos, D. S.; Grant, S. F. A.; Polychronakos, C. (American Diabetes Association, 2008-04)
    OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one locus at 16p13 was detected (P = 1.03 × 10−10) and confirmed in two additional cohorts. Here we describe the results of testing, in ...
  • ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry 

    Sleiman, P. M. A.; Annaiah, K.; Imielinski, M.; Bradfield, J. P.; Kim, C. E.; Frackelton, E. C.; Glessner, J. T.; Eckert, A. W.; Otieno, F. G.; Santa, E.; Thomas, K.; Smith, R. M.; Glaberson, W.; Garris, M.; Gunnlaugsson, S.; Chiavacci, R. M.; Allen, J.; Spergel, J.; Grundmeier, R.; Grunstein, M. M.; Magnusson, M.; Bisgaard, H.; Grant, S. F. A.; Hakonarson, H. (Elsevier, 2008-12)
  • Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn’s Disease 

    Baldassano, R. N.; Bradfield, J. P.; Monos, D. S.; Kim, C. E.; Glessner, J. T.; Casalunovo, T.; Frackelton, E. C.; Otieno, F. G.; Kanterakis, S.; Shaner, J. L.; Smith, R. M.; Eckert, A. W.; Robinson, L. J.; Onyiah, C. C.; Abrams, D. J.; Chiavacci, R. M.; Skraban, R.; Devoto, M.; Grantemail, S. F. A.; Hakonarson, H. (WB Saunders, 2007-08)
    Background & Aims: Recently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn’s disease (CD) as a consequence of a genome-wide ...
  • A Genome-Wide Association Study Identifies a Locus for Nonsyndromic Cleft Lip with or without Cleft Palate on 8q24 

    Otieno, George Ochieng; Grant, S. F. A.; Wang, K.; Zhang, H.; Glaberson, W.; Annaiah, K.; Kim, C. E.; Bradfield, J. P.; Glessner, J. T.; Thomas, K. A.; Garris, M.; Frackelton, E. C.; Chiavacci, R. M.; Nah, H.; Kirschner, R. E.; Hakonarson, H. (2009-12)
    Objective To identify, in a non-hypothesis manner, novel genetic factors associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P). Study design We performed a genome-wide association study in a ...
  • The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI 

    Otieno, George Ochieng; Zhao, J.; Bradfield, J. P.; Li, M.; Wang, K.; Zhang, H.; Kim, C. E.; Annaiah, K.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Otieno, F. G.; Shaner, J. L.; Smith, R. M.; Chiavacci, R. M.; Berkowitz, R. I.; Hakonarson, H.; Grant, S. F. A. (Wiley, 2009-12)
    The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade. Besides environmental factors, genetic factors are known to play an important role in the pathogenesis ...
  • Investigation of the Locus Near MC4R With Childhood Obesity in Americans of European and African Ancestry 

    Otieno, George Ochieng; Grant, S. F. A.; Bradfield, J. P.; Zhang, H.; Wang, K.; Kim, C. E.; Annaiah, K.; Santa, E.; Glessner, J. T.; Thomas, K.; Garris, M.; Frackelton, E. C.; Shaner, J. L.; Smith, R. M.; Imielinski, M.; Chiavacci, R. M.; Li, M.; Berkowitz, R. I.; Hakonarson, H. (Wiley, 2009-07)
    Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3′ of the MC4R locus as a consequence of a meta-analysis of genome-wide ...
  • Association of the TRAF1–C5 locus on chromosome 9 with juvenile idiopathic arthritis 

    Otieno, George Ochieng; Behrens, E. M.; Finkel, T. H.; Bradfield, J. P.; Kim, C. E.; Linton, L.; Casalunovo, T.; Frackelton, E. C.; Santa, E.; Glessner, J. T.; Chiavacci, R. M.; Grant, S. F. A.; Hakonarson, H. (Wiley, 2008-07)
  • Food Security Problems in Borabu Division, Nyamira District 

    Keraka, M. (Food Security Problems in Borabu Division, Nyamira District, 2005-09-13)
    This paper highlights the food security problems in Borabu Division, Nyamira District. It focuses on the concept of the relationship between population growth and land use. Secondly, it examines the influence of changing ...
  • Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP 

    Otieno, George Ochieng; Grant, S.F.; Li, M.; Bradfield, J.P.; Kim, C.E.; Annaiah, K.; Santa, E.; Glessner, J.T.; Casalunovo, T.; Frackelton, E.C.; Shaner, J.L.; Smith, R.M.; Imielinski, M.; Eckert, A.W.; Chiavacci, R.M.; Berkowitz, R.I.; Hakonarson, H. (Public Library of Science, 2008-03)
    Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. ...
  • Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease 

    Otieno, George Ochieng; Kugathasan, S.; Baldassano, R.N.; Bradfield, J.P.; Sleiman, P.M.; Imielinski, M.; Guthery, S.L.; Cucchiara, S.; Kim, C.E.; Frackelton, E.C.; Annaiah, K.; Glessner, J.T.; Santa, E.; Willson, T.; Eckert, A.W.; Bonkowski, E.; Shaner, J.L.; Smith, R.M.; Peterson, N.; Abrams, D.J.; Chiavacci, R.M.; Grundmeier, R.; Mamula, P.; Tomer, G.; Piccoli, D.A.; Monos, D.S.; Annese, V.; Denson, L.A.; Grant, S.F.; Hakonarson, H. (Nature Publishing Group -, 2008-09)
    Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology that involves both genetic and environmental triggers, including but not limited to defects in bacterial clearance, defective mucosal ...
  • High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications 

    Ochieng, Otieno, George; Shaikh, T.H.; Gai, X.; Perin, J.C.; Glessner, J.T.; Casalunovo, T.; Xie, H.; Murphy, K.; O'Hara, R.; Conlin, L.K.; D'Arcy, M.; Frackelton, E.C.; Geiger, E.A.; Haldeman-Englert, C.; Imielinski, M.; Kim, C.E.; Medne, L.; Annaiah, K.; Bradfield, J.P.; Dabaghyan, E. (Cold Spring Harbor Laboratory Press, 2009-09-19)
    We present a database of copy number variations (CNVs) detected in 2026 disease-free individuals, using high-density, SNP-based oligonucleotide microarrays. This large cohort, comprised mainly of Caucasians (65.2%) and ...
  • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes 

    Otieno, George Ochieng; Glessner, J.T.; Wang, K.; Cai, Guiqing; Korvatska, Olena; Kim, Cecilia. E.; Wood, Shawn (Nature Publishing Group, 2009-05-28)
    Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies focusing on candidate genes or genomic regions have identified several copy number variations (CNVs) ...

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