Recent Submissions

  • Vocal local versus pharmacological treatments for pain management in tubal ligation procedures in rural Kenya: a non-inferiority trial 

    Ochieng, G.O.; Keogh, Sarah C.; Fry, Kenzo; Mbugua, Edwin; Ayallo, Mark; Quinn, Heidi; Ngo, Thoai D. (BioMed Central, 2014)
    Background: Vocal local (VL) is a non-pharmacological pain management technique for gynecological procedures. In Africa, it is usually used in combination with pharmacological analgesics. However, analgesics are associated ...
  • Whole-genome sequencing in an autism multiplex family 

    Otieno, F. G.; Shi, L.; Zhang, X.; Golhar, R.; He, M.; Hou, C.; Kim, C.; Keating, B.; Lyon, G.J.; Wang, K.; Hakonarson, H. (BioMed Central, 2013)
    Background: Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for ...
  • Whole-genome DNA/RNA sequencing identifies truncating mutations in RBCK1 in a novel Mendelian disease with neuromuscular and cardiac involvement 

    Otieno, F. G.; Wang, Kai; Kim, Cecilia; Bradfield, Jonathan; Guo, Yunfei; Toskala, Elina; Hou, Cuiping; Thomas, Kelly; Cardinale, Christopher; Lyon, Gholson J; Golhar, Ryan; Hakonarson, Hakon (BioMed Central, 2013)
    Background: Whole-exome sequencing has identified the causes of several Mendelian diseases by analyzing multiple unrelated cases, but it is more challenging to resolve the cause of extremely rare and suspected Mendelian ...
  • Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. 

    Otieno, F. G.; Lanktree, M.B.; Guo, Y.; Murtaza, M.; Glessner, J.T. (Elsevier, 2011)
    Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 ...
  • Erratum to: AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R. M.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate. 

    Otieno, F. G.; Falk, M.J.; Li, D.; Gai, X.; McCormick, E.; Place, E.; Lasorsa, F.M.; Hou, C.; Kim, C.E.; Abdel-Magid, N.; Vazquez, L.; Mentch, F.D.; Chiavacci, R. M.; Liang, J.; Liu, X.; Jiang, H.; Giannuzzi, G.; Marsh, E.D.; Yiran, G.; Tian, L.; Palmieri, F.; Hakonarson, H. (2014)
    BACKGROUND: Whole exome sequencing (WES) offers a powerful diagnostic tool to rapidly and efficiently sequence all coding genes in individuals presenting for consideration of phenotypically and genetically heterogeneous ...
  • Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population 

    Otieno, F. G.; Matsunami, Nori; Hensel, Charles H; Baird, Lisa; Stevens, Jeff; Otterud, Brith; Leppert, Tami; Varvil, Tena; Hadley, Dexter; Glessner, Joseph T; Pellegrino, Renata; Kim, Cecilia; Thomas, Kelly; Wang, Fengxiang; Ho, Karen; Christensen, Gerald B; Li, Dongying; Prekeris, Rytis; Lambert, Christophe G; Hakonarson, H.; Leppert, Mark F (BioMed Central, 2014)
    Background: Genetics clearly plays a major role in the etiology of autism spectrum disorders (ASDs), but studies to date are only beginning to characterize the causal genetic variants responsible. Until recently, studies ...
  • Factors Influencing Diffusion of Electronic Medical Records: A Case Study in Three Healthcare Institutions in Japan 

    Otieno, G. O.; Hosoi, R. (The Health Information Management Association of Australia Limited, 2006)
    This study examines the effect of three factors: information technology (IT) skills of healthcare workers, present status of computerisation in their organisations, and workers' attitudes on the diffusion of electronic ...
  • A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study 

    Hakonarson, H.; Qu, H.; Bradfield, J. P.; Marchand, L.; Kim, C. E.; Glessner, J. T.; Grabs, R.; Casalunovo, T.; Taback, S. P.; Frackelton, E. C.; Eckert, A. W.; Annaiah, K.; Lawson, M. L.; Otieno, George Ochieng; Santa, E.; Shaner, J. L.; Smith, R. M.; Onyiah, C. C.; Skraban, R.; Chiavacci, R. M.; Robinson, L. J.; Stanley, C. A.; Kirsch, S. E.; Devoto, M.; Monos, D. S.; Grant, S. F. A.; Polychronakos, C. (American Diabetes Association, 2008-04)
    OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes, one locus at 16p13 was detected (P = 1.03 × 10−10) and confirmed in two additional cohorts. Here we describe the results of testing, in ...
  • ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry 

    Sleiman, P. M. A.; Annaiah, K.; Imielinski, M.; Bradfield, J. P.; Kim, C. E.; Frackelton, E. C.; Glessner, J. T.; Eckert, A. W.; Otieno, F. G.; Santa, E.; Thomas, K.; Smith, R. M.; Glaberson, W.; Garris, M.; Gunnlaugsson, S.; Chiavacci, R. M.; Allen, J.; Spergel, J.; Grundmeier, R.; Grunstein, M. M.; Magnusson, M.; Bisgaard, H.; Grant, S. F. A.; Hakonarson, H. (Elsevier, 2008-12)
  • Food Security Problems in Borabu Division, Nyamira District 

    Keraka, M. (Food Security Problems in Borabu Division, Nyamira District, 2005-09-13)
    This paper highlights the food security problems in Borabu Division, Nyamira District. It focuses on the concept of the relationship between population growth and land use. Secondly, it examines the influence of changing ...
  • Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP 

    Grant, S.F.; Li, M.; Bradfield, J.P.; Kim, C.E.; Annaiah, K.; Santa, E.; Glessner, J.T.; Casalunovo, T.; Frackelton, E.C.; Otieno, George Ochieng; Shaner, J.L.; Smith, R.M.; Imielinski, M.; Eckert, A. W.; Chiavacci, R. M.; Berkowitz, R.I.; Hakonarson, H. (Public Library of Science, 2008-03)
    Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. ...
  • High-resolution mapping and analysis of copy number variations in the human genome: a data resource for clinical and research applications 

    Ochieng, Otieno, George; Shaikh, T.H.; Gai, X.; Perin, J.C.; Glessner, J.T.; Casalunovo, T.; Xie, H.; Murphy, K.; O'Hara, R.; Conlin, L.K.; D'Arcy, M.; Frackelton, E.C.; Geiger, E.A.; Haldeman-Englert, C.; Imielinski, M.; Kim, C.E.; Medne, L.; Annaiah, K.; Bradfield, J.P.; Dabaghyan, E. (Cold Spring Harbor Laboratory Press, 2009-09-19)
    We present a database of copy number variations (CNVs) detected in 2026 disease-free individuals, using high-density, SNP-based oligonucleotide microarrays. This large cohort, comprised mainly of Caucasians (65.2%) and ...
  • Knowledge and Acceptability of Pap Smears, Self-sampling and HPV Vaccination among Adult Women in Kenya. 

    Rositch, A. F.; Gatuguta, A.; Choi, R. Y.; Guthrie, B. L.; Mackelprang, R. D.; Bosire, R; Manyara, L.; Kiarie, J. N.; Smith, J. S.; Farquhar, C. (2012)
    OBJECTIVES: Our study aimed to assess adult women's knowledge of human papillomavirus (HPV) and cervical cancer, and characterize their attitudes towards potential screening and prevention strategies. METHODS: Women ...
  • Sophistication of information technology in healthcare: a comparison among a sample of hospitals in Japan 

    Otieno, George Ochieng; Toyama, Hinako; Asonuma, Motohiro; Koide, Daisuke; Naitoh, Keiko (Electronic Journal of Health Informatics, 2007)
    This study examines the level of clinical sophistication of information technology (IT) in a sample of hospitals in Japan and benchmarks the extent of clinical sophistication in Japan with the findings from similar surveys ...