A New Pterocarpan from the Leaves of Abrus Pretorius L.
Malele, Catherine N.
Thoruwa, C. L.
Guantai, Anastasia N.
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A pterocarpan, 2,3,4,8-tetramethoxy-6a,11a-dihydro-6H-benzo[4,5]furo[3,2-c]chromene-7,9-diol (compound 1) was isolated from the dichloromethane extract of the leaves of Abrus precatorius L. The structure of the compound was elucidated by detailed spectroscopic analysis such as 1 H NMR, 13C NMR, distortionless enhancement by polarisation transfer (DEPT), heteronuclear multiple-quantum correlation (HMQC) and heteronuclear multiple-bond correlation (HMBC). The crude extracts displayed brine shrimp lethality and in vitro antimalarial activity. The methanolic crude extract demonstrated an A/B ratio of 9.7 signifying that it is more toxic against Plasmodium falciparum than brine shrimp.