Schistosoma mansoni: Effects on tryptophan metabolism in mice

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Show simple item record Njagi, E.N.M. Bender, D. A. 2014-07-22T09:11:28Z 2014-07-22T09:11:28Z 1990-01
dc.identifier.citation Experimental Parasitology Volume 70, Issue 1, January 1990, Pages 43–54 en_US
dc.identifier.issn 0014-4894
dc.identifier.other 1090-2449
dc.description DOI: 10.1016/0014-4894(90)90084-P en_US
dc.description.abstract In mice, infection with 20–30 cercariae of Schistosoma mansoni resulted in a considerable reduction in the formation of 14CO2 from [14C]tryptophan. Infected animals excreted significantly lower amounts of kynurenine, kynurenic acid, and methyl pyridone carboxamide than did uninfected controls. There was no difference in the ability of hepatocytes isolated from infected or control animals to metabolise [14C]tryptophan. Hepatocytes from infected animals synthesized less NAD(P), but more niacin and N1-methyl nicotinamide from tryptophan. They showed no greater accumulation of kynurenine metabolites than did cells from control animals. The hepatocyte content of pyridoxal phosphate and the erythrocyte aspartate aminotransferase activation coefficient were the same in both groups of mice, suggesting that infection with S. mansoni does not deplete vitamin B6. The impairment of tryptophan metabolism in vivo was apparently not due to impaired hepatic metabolism. Rather, it seems likely that the parasites or their eggs take up tryptophan avidly from the host's circulation. Studies of parasite and egg metabolism of tryptophan may suggest novel approaches to the chemotherapy Of bilharzia. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Schistosoma mansoni en_US
dc.subject Tryptophan metabolism en_US
dc.subject Niacin synthesis en_US
dc.subject Vitamin B6 en_US
dc.title Schistosoma mansoni: Effects on tryptophan metabolism in mice en_US
dc.type Article en_US

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